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Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

Figure 2

Validation of 29 previously published NSCLC biomarkers.

Meta-analysis of these genes and signatures in the respective sample cohort yielded CCNE1, CDC2 and CADM1 as the best performing individual genes (A–C) and the signature of Yamauchi et al. (D). A funnel plot depicting the hazard ratios (with confidence intervals) versus sample number for CDC2 and VEGF shows more reliable estimation with larger database sizes (E–F).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0082241.g002