Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation
Figure 4
Effect of fructose-induced insulin resistance (10% in drinking water, for 12 weeks) and daily oral administration of quercetin (50 mg.kg−1) on NF-κB activation.
Symbols indicate mean ± SEM for N = 6–8 animals; *P<0.05, **P<0.01, ***P<0.001, compared with the corresponding control group values; #P<0.05, ##P<0.01, ###P<0.001 compared with the corresponding insulin resistant group values; by One Way ANOVA and Newman Keuls post hoc test. Photos at the bottom are representative fluorescence images of aorta cross sections immunofluorescence stained by NF-κB antibody followed by Rhodamine conjugated secondary antibody. Photos at the right top corner are aorta cross section of IR group and its negative control (without the primary antibody).