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Cholinergic Neuromodulation Changes Phase Response Curve Shape and Type in Cortical Pyramidal Neurons

Figure 5

Charbachol induced PRC type I switch with mean firing rate normalized.

PRCs averaged over all neurons showing a transition from a type II to a type I PRC in response to the bath-application of carbachol, but only including ISIs ranging from 400 (2.5 Hz) to 200 ms (5 Hz). Figure conventions as in Fig. 3.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0003947.g005