Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial
Fig 1
Differential methylation results with respect to GDM and 1-h PG.
(A+E) Manhattan plots highlighting GDM and 1-h PG-associated dmCpGs. The black line represents p = 1 × 10−5, while the red line represents Bonferroni p = 1.29 × 10−7. (B+F) Volcano plot of the methylation results with respect to GDM and 1-h PG levels, with significant dmCpGs highlighted in red. (C+G) Pie chart showing the proportions of dmCpGs showing increased or decreased methylation (left panel) and showing the proportions of the locations relative to CpG islands (right panel). (D+H) Plot of the top dmCpG associated with GDM (cg03566881) and 1-h PG (cg26027170) as measured on the EPIC. CpG, cytosine-phosphate-guanine; dmCpG, differentially methylated CpG; FDR, false discovery rate; GDM, gestational diabetes mellitus; logFC, log fold change; PG, plasma glucose.