Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value
Figure 1
Unsupervised gene expression analysis of the discovery set of 443 colon cancers.
(A) Consensus matrix heatmap defining six clusters of samples for which consensus values range from 0 (in white, samples never clustered together) to 1 (dark blue, samples always clustered together). (B) Distance between clusters according to the hierarchical clustering of the 1,459 probe sets based on the centroids of each cluster. (C) GEP heatmap of the 1,459 probe sets ordered by subtype, with annotations associated with each subtype.