Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

Figure 6

Results of the single pass perfusion of CFDA SE (outflow concentrations).

For perfusion by CFDA SE, the large plot (left) shows the outflowing CFDA SE concentration in the healthy state of the isolated mouse liver model and the two steatotic states for a CFDA SE inflow during seconds. For comparison, results for a PBPK simulation are shown as well. The four small plots (right) show the mean CFDA SE concentrations in the four subspaces of the homogenized hepatic space as well as the ranges between 5th/95th and 25th/75th percentiles, respectively, to illustrate the ranges of the concentrations in the spatially resolved model. The PBPK simulation results, shown for comparison, in contrast yield one value for each compartment at any given time point, representing only mean values.

doi: https://doi.org/10.1371/journal.pcbi.1003499.g006