Abstract
Transforming growth factor beta (TGF-β) signaling leads to a number of biological end points involving cell growth, differentiation, and morphogenesis. Typically, the cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell differentiation. However, during pathological conditions, these defined effects of TGF-β can be reversed; for example, the growth-inhibitory effect is replaced with its tumor promoting ability. A multitude of factors and cross-signaling pathways have been reported to be involved in modulating the dual effects of TGF-β. In this review, we focus on the potential role of TGF-β signal transduction during development of neural progenitor cells and its relation to glioblastoma development from neural stem cells.
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References
Akhurst RJ and Derynck R . (2001). Trends Cell Biol., 11, S44–S51.
Anderson DJ . (2001). Neuron, 30, 19–35.
Attisano L and Wrana JL . (1998). Curr. Opin. Cell Biol., 10, 188–194.
Bar-Sagi D and Feramisco JR . (1985). Cell, 42, 841–848.
Barcellos-Hoff MH and Ewan KB . (2000). Breast Cancer Res., 2, 92–99.
Bennett V and Baines AJ . (2001). Physiol. Rev., 81, 1353–1392.
Bennett V, Davis J and Fowler WE . (1982). Nature, 299, 126–131.
Birkenmeier CS, McFarland-Starr EC and Barker JE . (1988). Proc. Natl. Acad. Sci. USA, 85, 8121–8125.
Bodmer S, Strommer K, Frei K, Siepl C, de Tribolet N, Heid I and Fontana A . (1989). J. Immunol., 143, 3222–3229.
Bottner M, Krieglstein K and Unsicker K . (2000). J. Neurochem., 75, 2227–2240.
Brionne TC, Tesseur I, Masliah E and Wyss-Coray T . (2003). Neuron, 40, 1133–1145.
Chen D, Zhao M and Mundy GR . (2004). Growth Factors, 22, 233–241.
Chesnutt C, Burrus LW, Brown AM and Niswander L . (2004). Dev. Biol., 274, 334–347.
Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A and Akhurst RJ . (1996). Cell, 86, 531–542.
da Cunha A, Jefferson JA, Jackson RW and Vitkovic L . (1993). J. Neuroimmunol., 42, 71–85.
Dahlstrand J, Lardelli M and Lendahl U . (1995). Brain Res. Dev. Brain Res., 84, 109–129.
Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H and Ruiz i Altaba A . (2001). Development, 128, 5201–5212.
Davis J and Bennett V . (1983). J. Biol. Chem., 258, 7757–7766.
De Matteis MA and Morrow JS . (2000). J. Cell Sci., 113 (Part 13), 2331–2343.
Deng MJ, Jin Y, Shi JN, Lu HB, Liu Y, He DW, Nie X and Smith AJ . (2004). Tissue Eng., 10, 1597–1606.
Derynck R . (1994). Trends Biochem. Sci., 19, 548–553.
Derynck R and Zhang YE . (2003). Nature, 425, 577–584.
Dubreuil RR, Wang P, Dahl S, Lee J and Goldstein LS . (2000). J. Cell Biol., 149, 647–656.
Fan Z, Lu Y, Wu X, DeBlasio A, Koff A and Mendelsohn J . (1995). J. Cell Biol., 131, 235–242.
Friese MA, Wischhusen J, Wick W, Weiler M, Eisele G, Steinle A and Weller M . (2004). Cancer Res., 64, 7596–7603.
Gage FH . (2000). Science, 287, 1433–1438.
Gage FH . (2002). J. Neurosci., 22, 612–613.
Gallagher PG and Forget BG . (1993). Semin. Hematol., 30, 4–20.
Galter D, Bottner M and Unsicker K . (1999). J. Neurosci. Res., 56, 531–538.
Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH and Kern SE . (1998). Cancer Res., 58, 5329–5332.
Gold LI . (1999). Crit. Rev. Oncog., 10, 303–360.
Goodman SR, Zimmer WE, Clark MB, Zagon IS, Barker JE and Bloom ML . (1995). Brain Res. Bull., 36, 593–606.
Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ, Kinzler KW, Vogelstein B, Willson JK and Markowitz S . (1999). Cancer Res., 59, 320–324.
Gross CG . (2000). Nat. Rev. Neurosci., 1, 67–73.
Halatsch ME, Gehrke E, Borhani FA, Efferth T, Werner C, Nomikos P, Schmidt U and Buchfelder M . (2003). Anticancer Res., 23, 2315–2320.
Hammarlund M, Davis WS and Jorgensen EM . (2000). J. Cell Biol., 149, 931–942.
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone Jr MA, Wrana JL and Falb D . (1997). Cell, 89, 1165–1173.
Hayashi S, Yamamoto M, Ueno Y, Ikeda K, Ohshima K, Soma G and Fukushima T . (2001). Neurol. Med. Chir. (Tokyo), 41, 187–195.
Hayes NV, Scott C, Heerkens E, Ohanian V, Maggs AM, Pinder JC, Kordeli E and Baines AJ . (2000). J. Cell Sci., 113 (Part 11), 2023–2034.
Held-Feindt J, Krisch B, Forstreuter F and Mentlein R . (2000). J. Physiol. Paris, 94, 251–258.
Heldin CH, Miyazono K and ten Dijke P . (1997). Nature, 390, 465–471.
Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M and Kornblum HI . (2003). Proc. Natl. Acad. Sci. USA, 100, 15178–15183.
Hideshima T, Mitsiades C, Akiyama M, Hayashi T, Chauhan D, Richardson P, Schlossman R, Podar K, Munshi NC, Mitsiades N and Anderson KC . (2003). Blood, 101, 1530–1534 (Epub 2002 Sep 26).
Hitoshi S, Tropepe V, Ekker M and van der Kooy D . (2002). Development, 129, 233–244.
Horst HA, Scheithauer BW, Kelly PJ and Kovach JS . (1992). Hum. Pathol., 23, 1284–1288.
Hu X and Zuckerman KS . (2001). J. Hematother. Stem Cell Res., 10, 67–74.
Humphrey PA, Gangarosa LM, Wong AJ, Archer GE, Lund-Johansen M, Bjerkvig R, Laerum OD, Friedman HS and Bigner DD . (1991). Biochem. Biophys. Res. Commun., 178, 1413–1420.
Isoe S, Naganuma H, Nakano S, Sasaki A, Satoh E, Nagasaka M, Maeda S and Nukui H . (1998). J. Neurosurg., 88, 529–534.
Izumoto S, Arita N, Ohnishi T, Hiraga S, Taki T, Tomita N, Ohue M and Hayakawa T . (1997). Cancer Lett., 112, 251–256.
Jennings MT, Hart CE, Commers PA, Whitlock JA, Martincic D, Maciunas RJ, Moots PL and Shehab TM . (1997). J. Neurooncol., 31, 233–254.
Jennings MT, Kaariainen IT, Gold L, Maciunas RJ and Commers PA . (1994). Hum. Pathol., 25, 464–475.
Jennings MT, Maciunas RJ, Carver R, Bascom CC, Juneau P, Misulis K and Moses HL . (1991). Int. J. Cancer, 49, 129–139.
Johnson MD, Jennings MT, Gold LI and Moses HL . (1993). Hum. Pathol., 24, 457–462.
Kawase Y, Yanagi Y, Takato T, Fujimoto M and Okochi H . (2004). Exp. Cell Res., 295, 194–203.
Kawauchi S, Beites CL, Crocker CE, Wu HH, Bonnin A, Murray R and Calof AL . (2004). Dev. Neurosci., 26, 166–180.
Kim J, Lo L, Dormand E and Anderson DJ . (2003). Neuron, 38, 17–31.
Kuan CT, Wikstrand CJ and Bigner DD . (2001). Endocr. Relat. Cancer, 8, 83–96.
Kumada T, Hasegawa A, Iwasaki Y, Baba H and Ikenaka K . (2004). Dev. Neurosci., 26, 68–76.
Levine J and Willard M . (1981). J. Cell Biol., 90, 631–642.
Lindholm D, Castren E, Kiefer R, Zafra F and Thoenen H . (1992). J. Cell Biol., 117, 395–400.
Lo L, Dormand E, Greenwood A and Anderson DJ . (2002). Development, 129, 1553–1567.
Lopez-Coviella I, Berse B, Thies RS and Blusztajn JK . (2002). J. Physiol. Paris, 96, 53–59.
Mann KM, Ray JL, Moon ES, Sass KM and Benson MR . (2004). J. Cell Biol., 165, 483–491.
Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW and Vogelstein B et al. (1995). Science, 268, 1336–1338.
Massague J . (1998). Annu. Rev. Biochem., 67, 753–791.
Massague J, Andres J, Attisano L, Cheifetz S, Lopez-Casillas F, Ohtsuki M and Wrana JL . (1992). Mol. Reprod. Dev., 32, 99–104.
Massague J, Blain SW and Lo RS . (2000). Cell, 103, 295–309.
Massague J and Weis-Garcia F . (1996). Cancer Surv., 27, 41–64.
Matsuura I, Denissova NG, Wang G, He D, Long J and Liu F . (2004). Nature, 430, 226–231.
Mentlein R, Eichler O, Forstreuter F and Held-Feindt J . (2001). Int. J. Cancer, 92, 545–550.
Merzak A, McCrea S, Koocheckpour S and Pilkington GJ . (1994). Br. J. Cancer, 70, 199–203.
Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B and Gearhart J . (1998). Int. J. Dev. Biol., 42, 221–224.
Mishra L, Cai T, Yu P, Monga SP and Mishra B . (1999). Oncogene, 18, 353–364.
Moon RT and McMahon AP . (1987). BioEssays, 7, 159–164.
Moorthy S, Chen L and Bennett V . (2000). J. Cell Biol., 149, 915–930.
Morrison SJ, Shah NM and Anderson DJ . (1997). Cell, 88, 287–298.
Moses HL and Serra R . (1996). Curr. Opin. Genet. Dev., 6, 581–586.
Munoz-Sanjuan I and Brivanlou AH . (2002). Nat. Rev. Neurosci., 3, 271–280.
Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J and Park K et al. (1995). Cancer Res., 55, 5545–5547.
Nagai S, Washiyama K, Kurimoto M, Takaku A, Endo S and Kumanishi T . (2002). J. Neurosurg., 96, 909–917.
Nakagawa T, Mabry M, de Bustros A, Ihle JN, Nelkin BD and Baylin SB . (1987). Proc. Natl. Acad. Sci. USA, 84, 5923–5927.
Nelson WJ and Veshnock PJ . (1986). J. Cell Biol., 103, 1751–1765.
Oft M, Peli J, Rudaz C, Schwarz H, Beug H and Reichmann E . (1996). Genes Dev., 10, 2462–2477.
Ohtsuka T, Ishibashi M, Gradwohl G, Nakanishi S, Guillemot F and Kageyama R . (1999). EMBO J., 18, 2196–2207.
Okano-Uchida T, Himi T, Komiya Y and Ishizaki Y . (2004). Proc. Natl. Acad. Sci. USA, 101, 1211–1216.
Panchision DM and McKay RD . (2002). Curr. Opin. Genet. Dev., 12, 478–487.
Panchision DM, Pickel JM, Studer L, Lee SH, Turner PA, Hazel TG and McKay RD . (2001). Genes Dev., 15, 2094–2110.
Pardal R, Clarke MF and Morrison SJ . (2003). Nat. Rev. Cancer, 3, 895–902.
Paulus W, Baur I, Huettner C, Schmausser B, Roggendorf W, Schlingensiepen KH and Brysch W . (1995). J. Neuropathol. Exp. Neurol., 54, 236–244.
Peng Y, Xu RH, Mei JM, Li XP, Yan D, Kung HF and Phang JM . (2002). Neuroscience, 109, 657–664.
Pera MF, Andrade J, Houssami S, Reubinoff B, Trounson A, Stanley EG, Ward-van Oostwaard D and Mummery C . (2004). J. Cell Sci., 117, 1269–1280.
Plate KH, Breier G, Farrell CL and Risau W . (1992). Lab. Invest., 67, 529–534.
Rajan P, Panchision DM, Newell LF and McKay RD . (2003). J. Cell Biol., 161, 911–921.
Reiss M . (1997). Oncol. Res., 9, 447–457.
Reiss M . (1999). Microbes Infect., 1, 1327–1347.
Reya T, Morrison SJ, Clarke MF and Weissman IL . (2001). Nature, 414, 105–111.
Riederer BM, Zagon IS and Goodman SR . (1986). J. Cell Biol., 102, 2088–2097.
Roberts AB and Sporn MB . (1993). Growth Factors, 8, 1–9.
Ruiz i Altaba A, Sanchez P and Dahmane N . (2002). Nat. Rev. Cancer, 2, 361–372.
Samuels V, Barrett JM, Bockman S, Pantazis CG and Allen Jr MB . (1989). Am. J. Pathol., 134, 894–902.
Schier AF and Talbot WS . (2001). Int. J. Dev. Biol., 45, 289–297.
Setoguchi T, Nakashima K, Takizawa T, Yanagisawa M, Ochiai W, Okabe M, Yone K, Komiya S and Taga T . (2004). Exp. Neurol., 189, 33–44.
Sieber-Blum M and Zhang JM . (1997). J. Anat., 191 (Part 4), 493–499.
Sihag RK, Shea TB and Wang FS . (1996). J. Neurosci. Res., 44, 430–437.
Sikorski AF and Goodman SR . (1991). Brain Res. Bull., 27, 195–198.
Sikorski AF, Sangerman J, Goodman SR and Critz SD . (2000). Brain Res., 852, 161–166.
Sonntag KC, Simantov R, Bjorklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM and Isacson O . (2005). Mol. Cell Neurosci., 28, 417–429.
Sporn MB . (1999). Microbes Infect., 1, 1251–1253.
Tang B, Bottinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ and Wakefield LM . (1998). Nat. Med., 4, 802–807.
Tang Y, Katuri V, Dillner A, Mishra B, Deng CX and Mishra L . (2003). Science, 299, 574–577.
Tang Y, Katuri V, Iqbal S, Narayan T, Wang Z, Lu RS, Mishra L and Mishra B . (2002). Oncogene, 21, 5255–5267.
Temple S . (2001). Nat. Rev. Neurosci., 2, 513–520.
Tsai RY, Kittappa R and McKay RD . (2002). Dev. Cell, 2, 707–712.
Tsai RY and McKay RD . (2000). J. Neurosci., 20, 3725–3735.
Tsai RY and McKay RD . (2002). Genes Dev., 16, 2991–3003.
Villanueva A, Garcia C, Paules AB, Vicente M, Megias M, Reyes G, de Villalonga P, Agell N, Lluis F, Bachs O and Capella G . (1998). Oncogene, 17, 1969–1978.
Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin Jr AS . (1998). Science, 281, 1680–1683.
Weissman IL, Anderson DJ and Gage F . (2001). Annu. Rev. Cell Dev. Biol., 17, 387–403.
Weller M and Fontana A . (1995). Brain Res. Brain Res. Rev., 21, 128–151.
Wrana JL . (2000). Cell, 100, 189–192.
Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W and Sommer L . (2005). Genes Dev., 19, 530–535.
Yamada N, Kato M, Yamashita H, Nister M, Miyazono K, Heldin CH and Funa K . (1995). Int. J. Cancer, 62, 386–392.
Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP and Taguchi H . (2004). Cancer Sci., 95, 176–180.
Yin D, Zhou H, Kumagai T, Liu G, Ong JM, Black KL and Koeffler HP . (2005). Oncogene, 24, 344–354.
Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massague J, Mundy GR and Guise TA . (1999). J. Clin. Invest., 103, 197–206.
Yung SY, Gokhan S, Jurcsak J, Molero AE, Abrajano JJ and Mehler MF . (2002). Proc. Natl. Acad. Sci. USA, 99, 16273–16278.
Zhang Y, Musci T and Derynck R . (1997). Curr. Biol., 7, 270–276.
Zhou YX, Zhao M, Li D, Shimazu K, Sakata K, Deng CX and Lu B . (2003). J. Biol. Chem., 278, 42313–42320 (Epub 2003 Aug 1).
Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E and Kotula L . (1998). J. Biol. Chem., 273, 13681–13692.
Acknowledgements
We would like to acknowledge Tiffany Blake and Vidhya Murugesan for their help with this article. This work was supported by NIH Grant R01 DK58637 (BM)
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Golestaneh, N., Mishra, B. TGF-β, Neuronal Stem Cells and Glioblastoma. Oncogene 24, 5722–5730 (2005). https://doi.org/10.1038/sj.onc.1208925
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