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Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians

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Abstract

Inflammatory reactions in the body have been shown to contribute to migraine development. Therefore, genes involved in the inflammatory pathways might play a role in the susceptibility and development of migraine. In this study, polymorphisms in tumor necrosis factor alpha (TNFα) and lymphotoxin alpha (LTA) genes were tested for association with migraine. A total of 398 participants (198 migraine patients and 200 controls) were recruited in the study. Serum TNF level was measured using a sandwich ELISA kit. Lymphocytes’ and monocytes’ counts were obtained from a differential complete blood count profile. Participants’ DNA was extracted and genotyped for rs1800629 and rs1799724 in TNFα, and rs909253 in LTA. Controls had a significantly higher mean lymphocyte count (P = 0.018), while the mean monocyte count and serum TNFα levels did not differ between the two groups (P > 0.05). With respect to gene polymorphisms, the rs1800629 and rs1799724 variants showed significant association with migraine in all subjects, and in males and females when analyzed separately (P < 0.001). The rs909253 did not show any statistical difference in frequencies among the two groups (P > 0.05). Having the A allele in rs1800629 was associated with a higher risk of migraine in both male (OR, 95%; CI, G/A = 3.79 [1.87-7.69]; A/A = 14.22 [1.67-121.14]; P < 0.01) and female (OR, 95%; G/A = 2.54 [1.47-4.38]; A/A = 2.52 [1.12-5.69]; P < 0.001) subjects. In conclusion, rs1800629 and rs1799724 in TNFα showed significant association with migraine among the Jordanian population.

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Data availability

The data that support the findings of this study are available from the corresponding author (K.A.) upon reasonable request.

References

  1. Migraine (2017). https://www.mayoclinic.org/diseases-conditions/migraine-headache/symptoms-causes/syc-20360201. (Accessed 5 November 2017 2017)

  2. Burstein R, Noseda R, Borsook D (2015) Migraine: multiple processes, complex pathophysiology. J Neurosci 35(17):6619–6629

    Article  CAS  Google Scholar 

  3. Elrington G (2002) Migraine: diagnosis and management. Journal of Neurology, Neurosurgery &amp; Psychiatry 72(suppl 2):ii10–ii15

    Google Scholar 

  4. Shah B, Dipesh RP (2017) Migraine review article. European J Biomed Pharm Sci 4:226–230

    CAS  Google Scholar 

  5. Woldeamanuel YW, Cowan RP (2017) Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants. J Neurol Sci 5(372)307–315

  6. Weatherall MW (2015) The diagnosis and treatment of chronic migraine. Ther Adv Chronic Dis 6(3):115–123

    Article  CAS  Google Scholar 

  7. Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, Serrano D, Lipton RB (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache 53(8):1278–1299

    Article  Google Scholar 

  8. Chawla J (2017) Migraine Headache. https://emedicine.medscape.com/article/1142556-overview. (Accessed 3 November 2017 2017).

  9. Chong CD, Dodick DW, Schlaggar BL, Schwedt TJ (2014) Atypical age-related cortical thinning in episodic migraine. Cephalalgia 34(14):1115–1124

    Article  Google Scholar 

  10. Hu F, Qian ZW (2016) Characteristic analysis of white matter lesions in migraine patients with MRI. Eur Rev Med Pharmacol Sci 20(6):1032–1036

  11. Shankar SV (2009) Effect of homoeopathicmedicines in the treatment ofmigraine, homoeopathic materia medica, DR. M.G.R. Medical University

  12. Teixido MCJ (2014) Migraine – More than a headache, John Hopkin's otolaryngology, Baltimore, Maryland

  13. Epidemiology and impact of headache and migraine (2016) https://americanheadachesociety.org/wp-content/uploads/2016/07/NAP_for_Web_-_Epidemiology___Impact_of_Headache___Migraine.pdf. (Accessed 3 November 2017 2017)

  14. Pietrobon D, Moskowitz MA (2013) Pathophysiology of migraine. Annu Rev Physiol 75:365–391

    Article  CAS  Google Scholar 

  15. Sedy J, Bekiaris V, Ware CF (2014) Tumor necrosis factor superfamily in innate immunity and inflammation. Cold Spring Harb Perspect Biol 7(4):a016279

    Article  Google Scholar 

  16. Fawzi MS, El-Shal AS, Rashad NM, Fathy HA (2015) Influence of tumor necrosis factor alpha gene promoter polymorphisms and its serum level on migraine susceptibility in Egyptian patients. J Neurol Sci 348(1-2):74–80

    Article  CAS  Google Scholar 

  17. Ates O, Kurt S, Altinisik J, Karaer H, Sezer S (2011) Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility. Pain Med 12(10):1464–1469

    Article  Google Scholar 

  18. Asuni C, Stochino ME, Cherchi A, Manchia M, Congiu D, Manconi F, Squassina A, Piccardi MP, Del Zompo M (2009) Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample. J Neurol 256(2):194–197

    Article  CAS  Google Scholar 

  19. Lee KA, Jang SY, Sohn KM, Won HH, Kim MJ, Kim JW, Chung CS (2007) Association between a polymorphism in the lymphotoxin-a promoter region and migraine. Headache 47(7):1056–1062

    Article  Google Scholar 

  20. Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition, Cephalalgia 38(1), 1-211

  21. Arab AH, Elhawary NA (2015) Association between ANKK1 (rs1800497) and LTA (rs909253) genetic variants and risk of schizophrenia. Biomed Res Int 2015:821827

    Article  Google Scholar 

  22. de Oliveira JG, Rossi AF, Nizato DM, Cadamuro AC, Jorge YC, Valsechi MC, Venancio LP, Rahal P, Pavarino EC, Goloni-Bertollo EM, Silva AE (2015) Influence of functional polymorphisms in TNF-alpha, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumour Biol 36(12):9159–9170

    Article  Google Scholar 

  23. Qiu B, Wang X, Zhang P, Shi C, Zhang J, Qiu W, Wang W, Li D (2012) Association of TNF-α promoter polymorphisms with the outcome of persistent HBV infection in a northeast Chinese Han population. Acta Biochim Biophys Sin 44(8):712–718

    Article  CAS  Google Scholar 

  24. Ghosh J, Joshi G, Pradhan S, Mittal B (2010) Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol 257(6):898–904

    Article  CAS  Google Scholar 

  25. Charles AC, Baca SM (2013) Cortical spreading depression and migraine. Nat Rev Neurol 9(11):637–644

    Article  Google Scholar 

  26. Uçar Karabulut K, Ugur Egercioglu T, Uyar M, Uçar Y (2016) The Change of Neutrophils/Lymphocytes Ratio in Migraine Attacks

  27. Peng Y-F, Wei Y, Qin Y-H, Wei Y-S, Teng Y-J, (2016) A relationship between absolute monocyte count and C-reactive protein in patients with migraine undergoing no pharmacological therapy, Clinical Chemistry and Laboratory Medicine (CCLM), p. e249

  28. Yılmaz IA, Özge A, Erdal ME, Edgünlü TG, Çakmak SE, Yalın OÖ (2010) Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med 11(4):492–497

    Article  Google Scholar 

  29. Trabace S, Brioli G, Lulli P, Morellini M, Giacovazzo M, Cicciarelli G, Martelletti P (2002) Tumor necrosis factor gene polymorphism in migraine, headache. The Journal of Head and Face Pain 42(5):341–345

    Article  Google Scholar 

  30. Rainero I, Grimaldi LME, Salani G, Valfrè W, Rivoiro C, Savi L, Pinessi L (2004) Association between the tumor necrosis factor-α −308 G/A gene polymorphism and migraine. Neurology 62(1):141–143

    Article  CAS  Google Scholar 

  31. Pappa S, Hatzistilianou M, Kouvatsi A, Pantzartzi C, Sakellaropoulou A, Pavlou E, Mavromichales I, Athanassiadou F (2010) Tumour necrosis factor gene polymorphisms and migraine in Greek children. Arch Med Sci 6(3):430–437

    Article  CAS  Google Scholar 

  32. Lee K-A, Yeon Jang S, Sohn K-M, Won H-H, Ji Kim M, Kim J-W, Chung C-S (2007) Association between a polymorphism in the lymphotoxin ? A Promoter Region and Migraine

  33. Liu R, Ma M, Cui M, Dong Z, Wang X, Zhang W, Yang M, Yu S (2014) Effects of tumor necrosis factor-beta (TNF-beta) 252A>G polymorphism on the development of migraine: a meta-analysis. PLoS One 9(6):e100189

    Article  Google Scholar 

  34. Schurks M, Kurth T, Buring JE, Zee RY (2009) A candidate gene association study of 77 polymorphisms in migraine. J Pain 10(7):759–766

    Article  Google Scholar 

  35. Schurks M, Rist PM, Zee RY, Chasman DI, Kurth T (2011) Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis. Cephalalgia 31(13):1381–1404

    Article  Google Scholar 

  36. Vgontzas A, Burch R (2018) Episodic migraine with and without aura: key differences and implications for pathophysiology, management, and assessing risks. Curr Pain Headache Rep 22(12):78

    Article  Google Scholar 

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Funding

Deanship of Research at Jordan University of Science and Technology (Project 388/2016).

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Authors and Affiliations

  1. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Nour Hamad, Samer F. Swedan & Omar F. Khabour

  2. Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Karem H. Alzoubi

  3. Department of Neurosciences, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Khalid El-Salem

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  1. Nour Hamad
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  2. Karem H. Alzoubi
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  3. Samer F. Swedan
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  4. Omar F. Khabour
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Correspondence to Karem H. Alzoubi.

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The authors declare that they have no conflicts of interest.

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The protocol of this study was approved by the Institutional Review Board (IRB) of Jordan University of Science and Technology, Irbid, Jordan.

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Written informed consent were obtained from all study participants.

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Hamad, N., Alzoubi, K.H., Swedan, S.F. et al. Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians. Neurol Sci 42, 3625–3630 (2021). https://doi.org/10.1007/s10072-020-04967-5

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  • DOI: https://doi.org/10.1007/s10072-020-04967-5

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