A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine"/>
[go: up one dir, main page]
Skip to main content

Advertisement

Springer Nature Link
Log in

Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

We aimed to look for the association of tumor necrosis factor (TNF) gene polymorphisms (TNFA 308G > A, and TNFB 252G > A) in genetic susceptibility to migraine. The pathogenesis of migraine involves many immune-mediated mechanisms in the vascular endothelium. TNF, being a potent immunomodulator and pro-inflammatory cytokine, is suggested to be involved in inflammatory reactions leading to migraine attacks. A total of 216 normotensive migraine patients, 160 tension type headache (TTH) patients and 216 healthy controls (HC) were recruited in the study. The genetic polymorphisms were investigated through SNP association analysis using a matched case control migraine population. Genotyping of TNFA 308G > A polymorphism and TNFB 252G > A was done using ARMS PCR and PCR–RFLP, respectively. A borderline association was observed in TNFA 308GA genotype in migraine patients versus HC (p = 0.043; OR = 1.763; 95% CI = 1.019–3.051). After sub-grouping migraine into migraine with aura (MA) or without aura, significant difference at genotypic (p = 0.015; OR = 2.293; 95% CI = 1.172–4.487) as well as allelic (p = 0.035; OR = 1.955; 95% CI = 1.047–3.651) level was evident. The difference was even more significant in female MA at genotypic (p = 0.006; OR = 2.901; 95% CI = 1.361–6.181) and allelic level (p = 0.017; OR = 2.318; 95% CI = 1.159–4.635) as well as for A allele carriers in MA [p value = 0.020; OR = 2.205 (1.132–4.295)] and female MA (p value = 0.008; OR = 2.741; CI = 1.297–5.792). No association of TNFB252G > A was observed in migraine patients or any subgroups. We did not find any association of TNFA or TNFB gene polymorphisms with TTH. In conclusion, the TNFA 308G > A polymorphism was found to be associated with MA, particularly in females, whereas we could not find any association of TNFB 252G > A polymorphism in genetic susceptibility to migraine on comparing the migraine patients with HC or TTH patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Asuni C, Stochino ME, Cherchi A, Manchia M, Congiu D, Manconi F, Squassina A, Piccardi MP, Zompo MD (2009) Migraine and tumour necrosis factor gene polymorphism—an association study in a Sardinian sample. J Neurol 256:194–197

    Article  CAS  PubMed  Google Scholar 

  2. Bettinotti MP, Hartung K, Deicher H, Messer G, Keller E, Weiss EH, Albert ED (1993) Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes. Immunogenetics 37:449–454

    Article  CAS  PubMed  Google Scholar 

  3. Bouma G, Crusius JB, Oudkerk PM, Kolkman JJ, von Blomberg BM, Kostense PJ, Giphart MJ, Schreuder GM, Meuwissen SG, Pena AS (1996) Secretion of tumour necrosis factor α and lymphotoxin α in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease. Scand J Immunol 43:456–463

    Article  CAS  PubMed  Google Scholar 

  4. Daly AK, Day CP (2001) Candidate gene case-control association studies: advantages and potential pitfalls. Br J Clin Pharmacol 52:489–499

    Article  CAS  PubMed  Google Scholar 

  5. Dawkins RL, Leaver A, Cameron PU, Martin E, Kay PH, Christiansen FT (1989) Some disease-associated ancestral haplotypes carry a polymorphism of TNF. Hum Immunol 26:91

    Article  CAS  PubMed  Google Scholar 

  6. Goeddel DV, Aggarwal BB, Gray PW, Leung DW, Nedwin GE, Palladino MA, Patton JS, Pennica D, Shepard HM, Sugarman BJ, Wong GHW (1986) Tumor necrosis factors: gene structure and biological activities. Cold Spring Harbor Symposia on Quantitative Biology, 597–609

  7. Goldfeld AE, Doyle C, Maniatis T (1990) Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. Proc Natl Acad Sci USA 87:9769–9773

    Article  CAS  PubMed  Google Scholar 

  8. Headache Classification Committee for the International Headache Society (HCCIHS) (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain, 1st edn. Cephalalgia 8(Suppl 7):1–96

    Google Scholar 

  9. Headache Classification Subcommittee of the International Headache Society (HCCIHS) (2004) The International Classification of Headache Disorders, 2nd edn. Cephalalgia 24(Suppl):1–160

  10. Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO (1990) Heritable major histocompatibility complex class II associated differences in production of tumor necrosis factor a: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 87:1233–1237

    Article  CAS  PubMed  Google Scholar 

  11. Jeanmonod P, Kanel RV, Mally FE, Fischer JE (2004) Elevated plasma C-reactive protein in chronically distressed subjects who carry the A allele of the TNF-α -308 G/A polymorphism. Psychosom Med 66:501–506

    Article  CAS  PubMed  Google Scholar 

  12. Joshi G, Pradhan S, Mittal B (2009) Role of estrogen receptor (ESRI PvuII and ESRI 325 C > G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. Cephalalgia [Epub Ahead of print]

  13. Joshi G, Pradhan S, Mittal B (2009) Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. J Neurol Sci 277(1–2):133–137

    Article  CAS  PubMed  Google Scholar 

  14. Kilding R, Iles MM, Timms JM, Worthington J, Wilson AG (2004) Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus. Arthritis Rheum 50:763–769

    Article  CAS  PubMed  Google Scholar 

  15. Launer LJ, Terwindt GM, Ferrari MD (1999) The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 53:537–542

    CAS  PubMed  Google Scholar 

  16. Makhatadze NJ (1998) Tumor necrosis factor locus: genetic organisation and biological implications. Hum Immunol 59:571–579

    Article  CAS  PubMed  Google Scholar 

  17. Martelletti P, Lulli P, Morellini M, Mariani B, Pennesi G, Cappellacci S, Brioli G, Giacovazzo M, Trabace S (1999) Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura. Hum Immunol 60:69–74

    Article  CAS  PubMed  Google Scholar 

  18. Mazaheri S, Hajilooi M, Rafiei A (2006) The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. J Neurol 253:1589–1593

    Article  CAS  PubMed  Google Scholar 

  19. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215

    Article  CAS  PubMed  Google Scholar 

  20. Perini F, D’Andrea G, Galloni E, Pignatelli F, Billo G, Alba S, Bussone G, Toso V (2005) Plasma cytokine levels in migraineurs and controls. Headache 45(7):926–931

    Article  PubMed  Google Scholar 

  21. Rainero I, Grimaldi LM, Salani G, Valfrè W, Rivoiro C, Savi L, Pinessi L (2004) Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. Neurology 62(1):141–143

    CAS  PubMed  Google Scholar 

  22. Sariban E, Imamura K, Leubbers R, Kufe D (1988) Transcriptional and post-transcriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest 81:1506–1510

    Article  CAS  PubMed  Google Scholar 

  23. Schurks M, Kurth T, Buring JE, Zee RYL (2009) A candidate gene association study of 77 polymorphisms in migraine. J Pain 10(7):759–766

    Article  PubMed  CAS  Google Scholar 

  24. Sharma S, Ghosh B, Sharma SK (2008) Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)-alpha levels in Asian Indians. Clin Exp Immunol 151(2):251–259

    Article  CAS  PubMed  Google Scholar 

  25. Sheffield RE (1998) Migraine prevalence—a literature review. Headache 38(8):595–601

    Article  CAS  PubMed  Google Scholar 

  26. Stewart WF, Lipton RB, Celentano DD, Reed ML (1992) Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA 267(1):64–69

    Article  CAS  PubMed  Google Scholar 

  27. Trabace S, Brioli G, Lulli P, Morellini M, Giacovazzo M, Cicciarelli G, Martelletti P (2002) Tumor necrosis factor gene polymorphism in migraine. Headache 42:341–345

    Article  PubMed  Google Scholar 

  28. Wilson AG, de Vries N, Pociot F, di Giovine FS, van de Putte LBA, Duff GW (1993) An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med 177:557–560

    Article  CAS  PubMed  Google Scholar 

  29. Wilson AG, di Giovine FS, Duff GW (1995) Genetics of tumor necrosis factor-α in autoimmune, infectious, and neoplastic diseases. J Inflamm 45:1–12

    CAS  PubMed  Google Scholar 

  30. Wilson AG, Symons JA, Mc Dowell TL, Mc Devitt HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. PNAS 94:3195–3199

    Article  CAS  PubMed  Google Scholar 

  31. Ye S, Dhillon S, Ke X, Collins AR, Day INM (2001) An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 29(17):e88

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

Financial assistance from the Indian Council of Medical Research, New Delhi, India is highly acknowledged.

Author information

Authors and Affiliations

  1. Department of Genetics, Raebareli Road, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, UP, India

    Jayashri Ghosh, Gunjan Joshi & Balraj Mittal

  2. Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, UP, India

    S. Pradhan

Authors
  1. Jayashri Ghosh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gunjan Joshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Pradhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Balraj Mittal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Balraj Mittal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ghosh, J., Joshi, G., Pradhan, S. et al. Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol 257, 898–904 (2010). https://doi.org/10.1007/s00415-009-5430-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-009-5430-x

Keywords