XRCC5

XRCC5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Dynodwyr
Cyfenwau	XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
Dynodwyr allanol	OMIM: 194364 HomoloGene: 40681 GeneCards: XRCC5
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nucleotide binding; • double-stranded telomeric DNA binding; • telomeric DNA binding; • GO:0008026 helicase activity; • 5'-deoxyribose-5-phosphate lyase activity; • GO:0004003 DNA helicase activity; • hydrolase activity, acting on acid anhydrides; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • ATP binding; • ubiquitin protein ligase binding; • double-stranded DNA binding; • damaged DNA binding; • RNA binding; • GO:0010577 enzyme activator activity; • GO:0032403 protein-containing complex binding; • DNA end binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nuclear telomere cap complex; • bilen; • Cellbilen; • nucleoplasm; • Cromosom; • nucleolus; • nonhomologous end joining complex; • cnewyllyn cell; • extracellular region; • secretory granule lumen; • protein-DNA complex; • Ku70:Ku80 complex; • GO:0009327 protein-containing complex; • site of DNA damage; • ribonucleoprotein complex;
Prosesau biolegol	• DNA recombination; • GO:0009373 regulation of transcription, DNA-templated; • regulation of smooth muscle cell proliferation; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • positive regulation of neurogenesis; • hematopoietic stem cell differentiation; • double-strand break repair; • negative regulation of t-circle formation; • establishment of integrated proviral latency; • cell population proliferation; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of type I interferon production; • cellular hyperosmotic salinity response; • GO:0100026 DNA repair; • DNA duplex unwinding; • brain development; • cellular response to fatty acid; • double-strand break repair via nonhomologous end joining; • neutrophil degranulation; • cellular response to gamma radiation; • cellular response to X-ray; • telomere maintenance; • regulation of telomere maintenance; • positive regulation of telomere maintenance via telomerase; • GO:0048554 positive regulation of catalytic activity; • positive regulation of protein kinase activity; • positive regulation of telomerase activity; • protein localization to chromosome, telomeric region; • cellular response to leukemia inhibitory factor; • activation of innate immune response; • immune system process; • innate immune response;
	Sources:Amigo / QuickGO
Orthologau
	7520
	n/a
	ENSG00000079246
	n/a
	P13010
	n/a
	NM_021141
	n/a
	NP_066964
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn XRCC5 yw XRCC5 a elwir hefyd yn X-ray repair cross complementing 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q35.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn XRCC5.

KU80
KUB2
Ku86
NFIV
KARP1
KARP-1

Llyfryddiaeth

"Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens. ". Invest Ophthalmol Vis Sci. 2015. PMID 26658510.
"Prognostic significance of Ku80 in pT2N0M0 esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. ". Tumour Biol. 2015. PMID 25758053.
"Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair. ". DNA Repair (Amst). 2017. PMID 29065392.
"DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). ". DNA Repair (Amst). 2017. PMID 28641126.
"Ku80 correlates with neoadjuvant chemotherapy resistance in human lung adenocarcinoma, but reduces cisplatin/pemetrexed-induced apoptosis in A549 cells.". Respir Res. 2017. PMID 28399858.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] XRCC5 - Cronfa NCBI

[1]

[2]