NTRK2

NTRK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Dynodwyr
Cyfenwau	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Dynodwyr allanol	OMIM: 600456 HomoloGene: 4504 GeneCards: NTRK2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• neurotrophin binding; • neurotrophin receptor activity; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • protein kinase activity; • brain-derived neurotrophic factor binding; • transferase activity; • protein homodimerization activity; • protein tyrosine kinase activity; • nucleotide binding; • brain-derived neurotrophic factor-activated receptor activity; • GO:0001948, GO:0016582 protein binding; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• cytosol; • endosome; • postsynaptic membrane; • bilen; • terminal bouton; • integral component of membrane; • receptor complex; • endosome membrane; • integral component of plasma membrane; • GO:0097483, GO:0097481 postsynaptic density; • early endosome; • early endosome membrane; • Cellbilen; • axon; • dendrite; • perinuclear region of cytoplasm; • cytoplasm; • cell projection; • dendritic spine; • axon terminus; • Golgi membrane;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • peripheral nervous system neuron development; • positive regulation of protein phosphorylation; • oligodendrocyte differentiation; • learning; • positive regulation of axonogenesis; • vasculogenesis; • protein phosphorylation; • central nervous system neuron development; • neuromuscular junction development; • retinal rod cell development; • Rhythm circadaidd; • feeding behavior; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of peptidyl-serine phosphorylation; • brain-derived neurotrophic factor receptor signaling pathway; • regulation of protein kinase B signaling; • regulation of metabolic process; • positive regulation of MAPK cascade; • cell differentiation; • phosphorylation; • neuron migration; • mechanoreceptor differentiation; • nervous system development; • glutamate secretion; • retina development in camera-type eye; • neuron differentiation; • cerebral cortex development; • negative regulation of anoikis; • multicellular organism development; • GO:1901313 positive regulation of gene expression; • positive regulation of cell population proliferation; • positive regulation of neuron projection development; • cellular response to amino acid stimulus; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • long-term potentiation; • positive regulation of synapse assembly; • transmembrane receptor protein tyrosine kinase signaling pathway; • protein autophosphorylation; • trans-synaptic signaling by neuropeptide, modulating synaptic transmission; • activation of phospholipase C activity; • neurotrophin TRK receptor signaling pathway; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • trans-synaptic signaling by BDNF, modulating synaptic transmission; • negative regulation of signal transduction; • neuronal action potential propagation; • myelination in peripheral nervous system; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • cellular response to nerve growth factor stimulus; • regulation of MAPK cascade; • cellular response to brain-derived neurotrophic factor stimulus;
	Sources:Amigo / QuickGO
Orthologau
	4915
	n/a
	ENSG00000148053
	n/a
	Q16620
	n/a
NM_001007097; NM_001018064; NM_001018065; NM_001018066; NM_001291937;
	NM_006180
	n/a
NP_001007098; NP_001018074; NP_001018075; NP_001018076; NP_001278866;
	NP_006171; NP_001356461; NP_001356462; NP_001356463; NP_001356464; NP_001356465; NP_001356466; NP_001356467; NP_001356468; NP_001356469; NP_001356470; NP_001356471; NP_001356472; NP_001356473; NP_001356474; NP_001356475; NP_001356476; NP_001356477; NP_001356478; NP_001356479; NP_001356480; NP_001356481
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTRK2 yw NTRK2 a elwir hefyd yn Neurotrophic receptor tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTRK2.

OBHD
TRKB
trk-B
GP145-TrkB

Llyfryddiaeth

"7,8-Dihydroxyflavone ameliorates high-glucose induced diabetic apoptosis in human retinal pigment epithelial cells by activating TrkB. ". Biochem Biophys Res Commun. 2018. PMID 29109000.
"Tyrosine receptor kinase B is a drug target in astrocytomas. ". Neuro Oncol. 2017. PMID 27402815.
"A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects. ". Transl Psychiatry. 2016. PMID 26978740.
"Tyrosine receptor kinase B silencing inhibits anoikisâ€‘resistance and improves anticancer efficiency of sorafenib in human renal cancer cells. ". Int J Oncol. 2016. PMID 26820170.
"Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.". Cancer Lett. 2016. PMID 26797418.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NTRK2 - Cronfa NCBI

[1]

[2]