CNR1

CNR1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE
Dynodwyr
Cyfenwau	CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain), cannabinoid receptor 1, cannabinoid CB1 receptor gene
Dynodwyr allanol	OMIM: 114610 HomoloGene: 7273 GeneCards: CNR1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled receptor activity; • signal transducer activity; • cannabinoid receptor activity; • GO:0001948, GO:0016582 protein binding; • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;
Cydrannau o'r gell	• integral component of membrane; • intracellular membrane-bounded organelle; • bilen; • growth cone; • integral component of plasma membrane; • axon; • membrane raft; • Cellbilen; • presynaptic membrane; • mitocondria; • mitochondrial outer membrane; • cell projection; • integral component of mitochondrial membrane; • presynapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of presynaptic membrane;
Prosesau biolegol	• negative regulation of nitric-oxide synthase activity; • negative regulation of mast cell activation; • glucose homeostasis; • response to nutrient; • regulation of insulin secretion; • negative regulation of blood pressure; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • maternal process involved in female pregnancy; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • response to nicotine; • GO:0010260 heneiddio; • positive regulation of fever generation; • Cof; • negative regulation of action potential; • regulation of feeding behavior; • negative regulation of ion transport; • response to morphine; • negative regulation of fatty acid beta-oxidation; • response to lipopolysaccharide; • positive regulation of blood pressure; • regulation of penile erection; • regulation of lipid metabolic process; • spermatogenesis; • positive regulation of neuron projection development; • positive regulation of apoptotic process; • positive regulation of acute inflammatory response to antigenic stimulus; • learning or memory; • sensory perception of pain; • negative regulation of dopamine secretion; • regulation of synaptic transmission, glutamatergic; • response to ethanol; • axonal fasciculation; • regulation of synaptic transmission, GABAergic; • GO:0072468 signal transduction; • adwaith i gocên; • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; • G protein-coupled receptor signaling pathway; • cannabinoid signaling pathway; • retrograde trans-synaptic signaling by endocannabinoid; • positive regulation of presynaptic cytosolic calcium concentration; • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologau
	1268
	n/a
	ENSG00000118432
	n/a
	P21554
	n/a
NM_001160226; NM_001160258; NM_001160259; NM_001160260; NM_016083;
	NM_033181; NM_001365869; NM_001365870; NM_001365872; NM_001365874; NM_001370545; NM_001370546; NM_001370547
	n/a
NP_001153698; NP_001153730; NP_001153731; NP_057167; NP_149421;
	NP_001352798; NP_001352799; NP_001352801; NP_001352803; NP_001357474; NP_001357475; NP_001357476
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CNR1 yw CNR1 a elwir hefyd yn Cannabinoid receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q15.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CNR1.

CB1
CNR
CB-R
CB1A
CB1R
CANN6
CB1K5

Llyfryddiaeth

"Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis. ". Pathol Int. 2017. PMID 27976824.
"Crystal Structure of the Human Cannabinoid Receptor CB1. ". Cell. 2016. PMID 27768894.
"Crystal structures of agonist-bound human cannabinoid receptor CB1. ". Nature. 2017. PMID 28678776.
"The CB1 Receptor as the Cornerstone of Exostasis. ". Neuron. 2017. PMID 28334603.
"The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.". Rev Bras Psiquiatr. 2017. PMID 28099629.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CNR1 - Cronfa NCBI

[1]

[2]