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Electroporation of tissues is modeled by taking into account two kinds of currents flowing respectively inside the cell and in the extracellular medium. This model takes into account capacitive effects. Simulations agrees with chronograms... more
Electroporation of tissues is modeled by taking into account two kinds of currents flowing respectively inside the cell and in the extracellular medium. This model takes into account capacitive effects. Simulations agrees with chronograms recorded in vivo on rabbit livers.
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Nowadays many tools exist for modelling electromagnetic fields in human body. However, the reliability of such a modelling is still an issue, due to the complexity of the human body and the uncertainty of many parameters. The accuracy of... more
Nowadays many tools exist for modelling electromagnetic fields in human body. However, the reliability of such a modelling is still an issue, due to the complexity of the human body and the uncertainty of many parameters. The accuracy of the Finite Element Method solution is linked to the quality of the mesh of the computational phantom. In this work we present a residual based error estimator to quantify the local numerical error which can be used with the classical Φ - A formulation
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A dynamic model of electroporation is proposed in order to compute at the tissue scale the distribution of the electric field during the application of the voltage pulse. In this approach, two kinds of density currents are considered: the... more
A dynamic model of electroporation is proposed in order to compute at the tissue scale the distribution of the electric field during the application of the voltage pulse. In this approach, two kinds of density currents are considered: the first one, derived from a model at the cell scale, flows through the cells and the second one flows through the extracellular medium. Simulations have been performed in relation with in vivo experiments made on rabbit livers: they show that the modeling is able to reproduce the chronograms of the current measured through the needles.
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International audienceWe propose a steady-state electrical current equation with a nonlinear Ohm's law to model irreversible electropermeabilization in a biological tissue. The nonlinear problem is solved using Picard's method and... more
International audienceWe propose a steady-state electrical current equation with a nonlinear Ohm's law to model irreversible electropermeabilization in a biological tissue. The nonlinear problem is solved using Picard's method and the unknown parameters in Ohm's law are estimated from the observation of the tissue necrosis in experiences in which different voltages are applied to samples of potatoes
Research Interests: Engineering, Computer Science, Computational Modeling, Uncertainty, Electroporation, and 14 morePhysical sciences, Conductivity, Mathematical Model, Voltage, Random Variables, Nonlinear system, Nonlinear Problems, Electrodes, Applied Voltages, Steady State Modeling, Electrical Current, Biological tissues, fixed-point iteration, and Nonlinear Conductivity
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The induced currents J into the body exposed to low frequency magnetic field of electrical device are computed by Finite Element Method, by using an anatomic 3D model of the body obtained from the Visible Human Project.... more
The induced currents J into the body exposed to low frequency magnetic field of electrical device are computed by Finite Element Method, by using an anatomic 3D model of the body obtained from the Visible Human Project. "Punctual" values of J onto the finite element nodes and averaged values onto 1cm3, are compared for various tissues, in order to assess the compliance with the ICNIRP guidelines. Particular attention is devoted to method calculation of average induced current.
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The fields induced in the human body by ELF electromagnetic fields are extremely weak, and hence very difficult to measure; therefore numerical dosimetry is an important issue. The most used formulation of magnetically induced fields is... more
The fields induced in the human body by ELF electromagnetic fields are extremely weak, and hence very difficult to measure; therefore numerical dosimetry is an important issue. The most used formulation of magnetically induced fields is the phi-a formulation, which takes ...
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This work tackles the evaluation of an algebraic multigrid method using inner flexible Krylov subspace iterations. It is applied to electro-quasistatic problems.
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ABSTRACT The invention relates to a device for measuring currents (3) in the conductors of a sheathed cable of a polyphase network, comprising at least three magnetic sensors (300) arranged around a central hole (312) through which the... more
ABSTRACT The invention relates to a device for measuring currents (3) in the conductors of a sheathed cable of a polyphase network, comprising at least three magnetic sensors (300) arranged around a central hole (312) through which the cable to be measured is intended to pass, the number of conductors in said cable being less than the number of sensors, and a calculation device (330) configured to: access a library of matrices [K] and [K]+, where [K]+ is a pseudo-inverse matrix of matrix [K]; form a vector [B] including a magnetic field measurement for each of the sensors; for various cable configurations and various angular positions of the sensors relative to the cables, calculate a residual vector [R] = [K].[K]+.[B] - [B]; select the matrix [K]+ for which the norm of the vector [R] is minimal; and calculate [1] = [K]+.[B], where [K]+ is the selected matrix.
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A technique based on feed-forward neural network (FFNN) for modeling rate-independent scalar magnetic hysteresis is presented in this paper. The neural network discussed here is inspired by several papers presented in the literature. The... more
A technique based on feed-forward neural network (FFNN) for modeling rate-independent scalar magnetic hysteresis is presented in this paper. The neural network discussed here is inspired by several papers presented in the literature. The training set is obtained by a Jiles–Atherton model, just to verify the feasibility of the method and to prevent measurements difficulties. We choose a FFNN model
Research Interests: Engineering, Mechanical Engineering, Computer Science, Condensed Matter Physics, Neural Network, and 8 moreHysteresis, Extreme Value Theory, Magnetism and Magnetic Materials, Artificial Neural Network, Feed Forward Neural Network, Preventive measures, Feed Forward Neural Networks, and Magnetic Hysteresis
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Electrical currents, induced into the human body by power-frequency magnetic fields, are computed by using the Finite Element method. The resolution is increased in a small region of major interest (brain, heart) by using a zooming... more
Electrical currents, induced into the human body by power-frequency magnetic fields, are computed by using the Finite Element method. The resolution is increased in a small region of major interest (brain, heart) by using a zooming method. Applications with simple sources of the exciting fields, as well as realistic power systems are presented.
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We compute by Finite Element the current induced in an heterogeneous model of the human body by both the electric and magnetic field generated by a 63 kV three-phase power line. Results are partially validated by comparison with existing... more
We compute by Finite Element the current induced in an heterogeneous model of the human body by both the electric and magnetic field generated by a 63 kV three-phase power line. Results are partially validated by comparison with existing data. It is found that induced currents due to both E and B are developed inside the body in an asymmetrical way.
Research Interests: Engineering and Dosimetry
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International audienceLes agrégats de cellules peuvent avantageusement être employés en guise de modèles intermédiaires entre la cellule unique et le tissu dans le cadre de l’étude multi-échelle du phénomène d’électroporation. De tels... more
International audienceLes agrégats de cellules peuvent avantageusement être employés en guise de modèles intermédiaires entre la cellule unique et le tissu dans le cadre de l’étude multi-échelle du phénomène d’électroporation. De tels assemblages peuvent être obtenus sur puce par diélectrophorèse (DEP)suivant une approche ascendante. Une interface graphique utilisateur a été développée pour faciliter le choix des paramètres expérimentaux. Des simulations multiphysiques ont été réalisées pour déterminer les configurations d’électrodes favorables au piégeage diélectrophorétique des cellules sous flux au sein d’une puce microfluidique. Après fabrication de la puce, des agrégats de cellules HEK (Human Embryonic Kidney )ont pu ainsi être obtenus par diélectrophorèse.Un dispositif expérimental pour la caractérisation électrique des cellules individuelles et des agrégats par spectroscopie d’impédance a également été développ
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In the daily life, we are exposed to electromagnetic fields. One of the sources of these fields is the natural environment, but they are also dues to the increasing number of electrical appliances. Thus one is more and more concerned with... more
In the daily life, we are exposed to electromagnetic fields. One of the sources of these fields is the natural environment, but they are also dues to the increasing number of electrical appliances. Thus one is more and more concerned with the issue of the effects of this exposure on human health. The low frequency magnetic fields generate induced currents into the human body. These currents may produce some minor, reversible effects (phosphenes) for J=100mA/m2. On the other hand, the long-term effects of this exposure remain not well known. Basing upon the Principle of Precautions, the governments are upgrading the industrial standards concerning non-ionizing radiations. For low frequency (magnetic) fields, some maximum admissible values are defined for the induced current density into the human body J, and for the flux density B. These limits have been defined on the basis of biological thresholds and simple analytical computations, with some security factors. The knowledge of the ...