TMED1

TMED1
Identifikatori
Aliasi	TMED1
Vanjski ID-jevi	OMIM: 605395 MGI: 106201 HomoloGene: 21360 GeneCards: TMED1
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	10,836,318 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	21,421,548 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• signaling receptor binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • Golđijev aparat; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • ćelijska membrana; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum; • COPII-coated ER to Golgi transport vesicle;
Biološki proces	• protein transport; • GO:0072468 Transdukcija signala; • cell-cell signaling; • intracellular protein transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • Golgi organization;
	Izvori:Amigo / QuickGO
Ortolozi
	11018
	17083
	ENSG00000099203
	ENSMUSG00000032180
	Q13445
	Q3V009
	NM_006858
	NM_010744; NM_001324510
	NP_006849
	NP_001311439; NP_034874
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski emp24 domen-sadržavajući protein 1 je protein koji je kod ljudi kodiran genom TMED1.^[5]^[6]^[7]

Protein kodiran ovim genom identificiran je njegovom interakcijom s receptorima poput interleukina 1 (IL1RL1). Ovaj protein nema nikakve sličnosti s drugim ligandima interleukina 1. Funkcionalni značaj njegove interakcije s IL1RL1 nije poznat.^[7]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MMAAGAALAL	ALWLLMPPVE	VGGAGPPPIQ	DGEFTFLLPA	GRKQCFYQSA
PANASLETEY	QVIGGAGLDV	DFTLESPQGV	LLVSESRKAD	GVHTVEPTEA
GDYKLCFDNS	FSTISEKLVF	FELIFDSLQD	DEEVEGWAEA	VEPEEMLDVK
MEDIKESIET	MRTRLERSIQ	MLTLLRAFEA	RDRNLQEGNL	ERVNFWSAVN
VAVLLLVAVL	QVCTLKRFFQ	DKRPVPT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.
^ Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.
^ ^a ^b "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

Dopunska literatura

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11466339-5] Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.

[pmid8621446-6] Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.

[entrez-7] "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

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