TARP

TARP
Identifikatori
Aliasi	TARP
Vanjski ID-jevi	OMIM: 609642 HomoloGene: 128237 GeneCards: TARP
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	38,265,678 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	445347
	n/a
	ENSG00000211689
	n/a
	Q0VGM3
	n/a
	NM_001003799; NM_001003806
	n/a
	NP_001003806.1
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein TCR gama alternativnog okvira čitanja, znan i kao TARP, je ljudski gen.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 111 aminokiselina, а molekulska težina 12.847 Da.^[4]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKTNDTYMKF	SWLTVPEKSL	DKEHRCIVRH	ENNKNGVDQE	IIFPPIKTDV
ITMDPKDNCS	KDANDTLLLQ	LTNTSAYYMY	LLLLLKSVVY	FAIITCCLLR
RTAFCCNGEK	S

Funkcija

U nekim nelimfoidnim tkivima, eksprimiren je needitirani receptor T-ćelija gama (TRG@). Rezultirajući transkript sadrži podskup segmenata gena TRG@ i kraći je od transkripata TRG@ eksprimiranih u limfoidnim tkivima.

Ovaj RefSeq zapis predstavlja neuređen transkript lokusa TRG@; kompletan TRG@ lokus predstavljen je genomskim RefSeq NG_001336. Transkript predstavljen ovim RefSeqom ima dva otvorena okvira čitanja (ORF) koji kodiraju različite proteine. Nizvodni ORF nalazi se u istom okviru kao i TRG@, a njegov proteinski proizvod sličan je TRG@ proteinima. Uzvodni ORF koristi drugačiji okvir čitanja i kodira novi protein.^[3]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000211689 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TARP TCR gamma alternate reading frame protein".
^ "UniProt, Q0VGM3" (jezik: engleski). Pristupljeno 27. 9. 2021.

Dopunska literatura

Yoshikai Y, Toyonaga B, Koga Y, et al. (1987). "Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells". Eur. J. Immunol. 17 (1): 119–26. doi:10.1002/eji.1830170120. PMID 2949984. S2CID 43458672.
Krangel MS, Band H, Hata S, et al. (1987). "Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes". Science. 237 (4810): 64–7. Bibcode:1987Sci...237...64K. doi:10.1126/science.2955517. PMID 2955517.
Tighe L, Forster A, Clark DM, et al. (1988). "Unusual forms of T cell gamma mRNA in a human T cell leukemia cell line: implications for gamma gene expression". Eur. J. Immunol. 17 (12): 1729–36. doi:10.1002/eji.1830171208. PMID 2961573. S2CID 84409741.
Littman DR, Newton M, Crommie D, et al. (1987). "Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism". Nature. 326 (6108): 85–8. Bibcode:1987Natur.326...85L. doi:10.1038/326085a0. PMID 3102973. S2CID 4260305.
Pelicci PG, Subar M, Weiss A, et al. (1987). "Molecular diversity of the human T-gamma constant region genes". Science. 237 (4818): 1051–5. Bibcode:1987Sci...237.1051P. doi:10.1126/science.3112943. PMID 3112943.
Essand M, Vasmatzis G, Brinkmann U, et al. (1999). "High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9287–92. Bibcode:1999PNAS...96.9287E. doi:10.1073/pnas.96.16.9287. PMC 17772. PMID 10430935.
Wolfgang CD, Essand M, Vincent JJ, et al. (2000). "TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9437–42. Bibcode:2000PNAS...97.9437W. doi:10.1073/pnas.160270597. PMC 16882. PMID 10931945.
Wolfgang CD, Essand M, Lee B, Pastan I (2001). "T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin". Cancer Res. 61 (22): 8122–6. PMID 11719440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cheng WS, Giandomenico V, Pastan I, Essand M (2003). "Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter". Endocrinology. 144 (8): 3433–40. doi:10.1210/en.2003-0121. PMID 12865322.
Maeda H, Nagata S, Wolfgang CD, et al. (2004). "The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria". J. Biol. Chem. 279 (23): 24561–8. doi:10.1074/jbc.M402492200. PMID 15150260.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000211689 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: TARP TCR gamma alternate reading frame protein".

[UniProt-4] "UniProt, Q0VGM3" (jezik: engleski). Pristupljeno 27. 9. 2021.

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