STX17

STX17
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4WY4,%%s4WY4
Identifikatori
Aliasi	STX17
Vanjski ID-jevi	OMIM: 604204 MGI: 1914977 HomoloGene: 9917 GeneCards: STX17
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	99,974,534 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	48,186,507 bp
Ontologija gena
Molekularna funkcija	• SNAP receptor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • protein phosphatase binding; • protein kinase binding; • SNARE binding;
Ćelijska komponenta	• HOPS complex; • citoplazma; • integral component of membrane; • citosol; • mitochondria associated membranes; • rough endoplasmic reticulum; • endoplasmic reticulum membrane; • membrana; • lysosomal membrane; • autophagosome membrane; • SNARE complex; • smooth endoplasmic reticulum membrane; • Endoplazmatski retikulum; • mitohondrija; • ER to Golgi transport vesicle membrane; • COPII-coated ER to Golgi transport vesicle; • endoplasmic reticulum-Golgi intermediate compartment membrane; • GO:0016023 citoplazmatska vezikula; • endoplasmic reticulum-Golgi intermediate compartment; • Autofagosom; • ćelijska membrana; • Endomembranski sistem;
Biološki proces	• endoplasmic reticulum-Golgi intermediate compartment organization; • Golgi organization; • protein localization to phagophore assembly site; • Autofagija; • endoplasmic reticulum to Golgi vesicle-mediated transport; • vesicle docking; • GO:0000046 autophagosome maturation; • intracellular protein transport; • Fuzija vezikula; • vesicle-mediated transport; • autophagosome membrane docking; • Egzocitoza;
	Izvori:Amigo / QuickGO
Ortolozi
	55014
	67727
	ENSG00000136874
	ENSMUSG00000061455
	P56962
	Q9D0I4
	NM_017919
	NM_026343
	NP_060389
	NP_080619
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintaksin-17 jest protein koji je kod ljudi kodiran genom STX17 sa hromosoma 9.^[5] Kod konja, duplikacija introna 6 uzrokuje progresivno sijedenje.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 302 aminokiseline, a molekulska težina 33.403 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEDEEKVKL	RRLEPAIQKF	IKIVIPTDLE	RLRKHQINIE	KYQRCRIWDK
LHEEHINAGR	TVQQLRSNIR	EIEKLCLKVR	KDDLVLLKRM	IDPVKEEASA
ATAEFLQLHL	ESVEELKKQF	NDEETLLQPP	LTRSMTVGGA	FHTTEAEASS
QSLTQIYALP	EIPQDQNAAE	SWETLEADLI	ELSQLVTDFS	LLVNSQQEKI
DSIADHVNSA	AVNVEEGTKN	LGKAAKYKLA	ALPVAGALIG	GMVGGPIGLL
AGFKVAGIAA	ALGGGVLGFT	GGKLIQRKKQ	KMMEKLTSSC	PDLPSQTDKK
CS

Također pogledajte

Sintaksin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136874 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061455 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Syntaxin 17".
^ "UC Davis Gray".

Dopunska literatura

Itakura E, Kishi-Itakura C, Mizushima N (2012). "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes". Cell. 151 (6): 1256–69. doi:10.1016/j.cell.2012.11.001. PMID 23217709.
Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010). "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity". Nature. 466 (7302): 113–7. Bibcode:2010Natur.466..113P. doi:10.1038/nature09114. PMC 2921172. PMID 20596022.
Muppirala M, Gupta V, Swarup G (2011). "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi". Biol. Cell. 103 (7): 333–50. doi:10.1042/BC20110006. PMID 21545355. S2CID 41507139.
Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Montgomery GW (2009). "Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma". Melanoma Res. 19 (2): 80–6. doi:10.1097/CMR.0b013e328322fc45. PMC 3665505. PMID 19209086.
Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
Steegmaier M, Oorschot V, Klumperman J, Scheller RH (2000). "Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics". Mol. Biol. Cell. 11 (8): 2719–31. doi:10.1091/mbc.11.8.2719. PMC 14951. PMID 10930465.

Vanjski linkovi

P56962

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136874 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061455 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Syntaxin 17".

[6] "UC Davis Gray".

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