STRBP

STRBP
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DMY
Identifikatori
Aliasi	STRBP
Vanjski ID-jevi	OMIM: 611138 MGI: 104626 HomoloGene: 7548 GeneCards: STRBP
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	123,268,586 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	37,593,871 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • double-stranded RNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • single-stranded RNA binding; • vezivanje sa RNK; • microtubule binding; • vezivanje tubulina;
Ćelijska komponenta	• citoplazma; • microtubule cytoskeleton; • jedro; • manchette;
Biološki proces	• multicellular organism development; • mechanosensory behavior; • Ćelijska diferencijacija; • Spermatogeneza; • spermatid development;
	Izvori:Amigo / QuickGO
Ortolozi
	55342
	20744
	ENSG00000165209
	ENSMUSG00000026915
	Q96SI9
	Q91WM1
	NM_001171137; NM_018387; NM_001376106; NM_001376107; NM_001376109
NM_009261; NM_176932; NM_001355259; NM_001379314; NM_001379315;
	NM_001379316
	NP_001164608; NP_060857; NP_001363035; NP_001363036; NP_001363038
	NP_033287; NP_001342188; NP_001366243; NP_001366244; NP_001366245
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Spermatidni perijedarni RNK-vezujući protein je protein koji je kod ljudi kodiran genom STRBP.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 672 aminokiseline, а molekulska težina 73.653 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRSIRSFAND	DRHVMVKHST	IYPSPEELEA	VQNMVSTVEC	ALKHVSDWLD
ETNKGTKTEG	ETEVKKDEAG	ENYSKDQGGR	TLCGVMRIGL	VAKGLLIKDD
MDLELVLMCK	DKPTETLLNT	VKDNLPIQIQ	KLTEEKYQVE	QCVNEASIII
RNTKEPTLTL	KVILTSPLIR	DELEKKDGEN	VSMKDPPDLL	DRQKCLNALA
SLRHAKWFQA	RANGLKSCVI	VLRILRDLCN	RVPTWAPLKG	WPLELICEKS
IGTCNRPLGA	GEALRRVMEC	LASGILLPGG	PGLHDPCERD	PTDALSYMTI
QQKEDITHSA	QHALRLSAFG	QIYKVLEMDP	LPSSKPFQKY	SWSVTDKEGA
GSSALKRPFE	DGLGDDKDPN	KKMKRNLRKI	LDSKAIDLMN	ALMRLNQIRP
GLQYKLLSQS	GPVHAPVFTM	SVDVDGTTYE	ASGPSKKTAK	LHVAVKVLQA
MGYPTGFDAD	IECMSSDEKS	DNESKNETVS	SNSSNNTGNS	TTETSSTLEV
RTQGPILTAS	GKNPVMELNE	KRRGLKYELI	SETGGSHDKR	FVMEVEVDGQ
KFRGAGPNKK	VAKASAALAA	LEKLFSGPNA	ANNKKKKIIP	QAKGVVNTAV
SAAVQAVRGR	GRGTLTRGAF	VGATAAPGYI	APGYGTPYGY	STAAPAYGLP
KRMVLLPVMK	FPTYPVPHYS	FF

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165209 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026915 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: STRBP spermatid perinuclear RNA binding protein".
^ "UniProt, Q96SI9". Pristupljeno 12. 9. 2021.

Dopunska literatura

Schumacher JM, Lee K, Edelhoff S, Braun RE (maj 1995). "Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules". The Journal of Cell Biology. 129 (4): 1023–32. doi:10.1083/jcb.129.4.1023. PMC 2120489. PMID 7744952.
Schumacher JM, Artzt K, Braun RE (juli 1998). "Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice". Biology of Reproduction. 59 (1): 69–76. doi:10.1095/biolreprod59.1.69. PMID 9674995.
Coolidge CJ, Patton JG (mart 2000). "A new double-stranded RNA-binding protein that interacts with PKR". Nucleic Acids Research. 28 (6): 1407–17. doi:10.1093/nar/28.6.1407. PMC 111047. PMID 10684936.
Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (septembar 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Pires-daSilva A, Nayernia K, Engel W, Torres M, Stoykova A, Chowdhury K, Gruss P (maj 2001). "Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities" (PDF). Developmental Biology. 233 (2): 319–28. doi:10.1006/dbio.2001.0169. hdl:11858/00-001M-0000-0012-F717-7. PMID 11336498.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (oktobar 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165209 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026915 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STRBP spermatid perinuclear RNA binding protein".

[UniProt-6] "UniProt, Q96SI9". Pristupljeno 12. 9. 2021.

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