NKTR

NKTR
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2HE9
Identifikatori
Aliasi	NKTR
Vanjski ID-jevi	OMIM: 161565 MGI: 97346 HomoloGene: 122148 GeneCards: NKTR
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	42,648,735 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	121,756,843 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• isomerase activity; • peptidyl-prolyl cis-trans isomerase activity; • cyclosporin A binding; • unfolded protein binding;
Ćelijska komponenta	• membrana; • nukleoplazma; • mitohondrija; • citosol; • ćelijska membrana; • jedro;
Biološki proces	• Savijanje proteina; • protein peptidyl-prolyl isomerization; • protein refolding;
	Izvori:Amigo / QuickGO
Ortolozi
	4820
	18087
	ENSG00000114857
	ENSMUSG00000032525
	P30414
	P30415
	NM_001012651; NM_005385; NM_001349124; NM_001349125; NM_001349126
	NM_010918
	NP_005376; NP_001336053; NP_001336054; NP_001336055
	NP_035048
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Regulatoroliki protein 2 dušik-permeaze (NPRL2) , znan i kao kandidat 4 za tumorskog supresora (TUSC4) jest protein koji je kod ljudi kodiran genom NPRL2 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 380 aminokiselina, а molekulska težina Da. 43 658^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGSGCRIECI	FFSEFHPTLG	PKITYQVPED	FISRELFDTV	QVYIITKPEL
QNKLITVTAM	EKKLIGCPVC	IEHKKYSRNA	LLFNLGFVCD	AQAKTCALEP
IVKKLAGYLT	TLELESSFVS	MEESKQKLVP	IMTILLEELN	ASGRCTLPID
ESNTIHLKVI	EQRPDPPVAQ	EYDVPVFTKD	KEDFFNSQWD	LTTQQILPYI
DGFRHIQKIS	AEADVELNLV	RIAIQNLLYY	GVVTLVSILQ	YSNVYCPTPK
VQDLVDDKSL	QEACLSYVTK	QGHKRASLRD	VFQLYCSLSP	GTTVRDLIGR
HPQQLQHVDE	RKLIQFGLMK	NLIRRLQKYP	VRVTREEQSH	PARLYTGCHS
YDEICCKTGM	SYHELDERLE	NDPNIIICWK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114857 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032525 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
^ "Entrez Gene: TUSC4 tumor suppressor candidate 4".
^ "UniProt, Q8WTW4" (jezik: engleski). Pristupljeno 4. 11. 2021.

Dopunska literatura

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research. 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (maj 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research. 62 (9): 2715–20. PMC 3478680. PMID 11980673.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114857 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032525 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11085536-5] Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.

[entrez-6] "Entrez Gene: TUSC4 tumor suppressor candidate 4".

[UniProt-7] "UniProt, Q8WTW4" (jezik: engleski). Pristupljeno 4. 11. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]