S Wikipedije, slobodne enciklopedije
Medijator ćelijske pokretljivosti 1 jest protein koji je kod ljudi kodiran genom MEMO1 sa hromosoma 2 .[ 5]
Dužina polipeptidnog lanca je 297 aminokiselina , a molkekulska iežina 33.733 Da .[ 6]
10 20 30 40 50 MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (mart 2009). "Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration" . Journal of Cell Science . 122 (Pt 6): 787–97. doi :10.1242/jcs.032094 PMID 19223396 . Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A (juni 2004). "Memo mediates ErbB2-driven cell motility". Nature Cell Biology . 6 (6): 515–22. doi :10.1038/ncb1134 . PMID 15156151 . S2CID 23073115 . Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (novembar 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics . 78 (1–2): 46–54. doi :10.1006/geno.2001.6640 . PMID 11707072 . Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (februar 2008). "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site" . The Journal of Biological Chemistry . 283 (5): 2734–40. doi :10.1074/jbc.M703523200 PMID 18045866 . Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (juni 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins" . BMC Genomics . 7 : 155. doi :10.1186/1471-2164-7-155 . PMC 1526728 PMID 16780588 . Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A (novembar 2008). "Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells" . The Journal of Cell Biology . 183 (3): 401–8. doi :10.1083/jcb.200805107 . PMC 2575782 PMID 18955552 . 
