S Wikipedije, slobodne enciklopedije
H4-liki histon jest protein koji je kod ljudi kodiran genom HIST1H4G sa hromosoma 6 .[ 3] [ 4] [ 5]
Dužina polipeptidnog lanca je 98 aminokiselina , a molekulska težina 11.009 Da .[ 5]
10 20 30 40 50 MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL IYEETRRVFK VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL
Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota . Dvije molekule svakog od četiri jezgarna histona (H2A , H2B , H3 i H4 ) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK-linkera između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element . Ovaj gen nalazi se u velikom klasteru histonskih gena na hromosomu 6 .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000275663 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics . 40 (2): 314–22. doi :10.1006/geno.1996.4592 . PMID 9119399 . ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b c "Entrez Gene: HIST1H4G histone cluster 1, H4g" .
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550–61. doi :10.1093/emboj/cdg631 . PMC 291826 PMID 14657027 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312–26. doi :10.1006/viro.2001.1129 PMID 11689053 . Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278–95. doi :10.1006/viro.2000.0593 PMID 11080476 . El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter" . Mol. Cell. Biol . 18 (5): 2535–44. doi :10.1128/mcb.18.5.2535 . PMC 110633 PMID 9566873 . Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet . 101 (3): 284–94. doi :10.1007/s004390050630 . PMID 9439656 . S2CID 38539096 . 
