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CLSPN

S Wikipedije, slobodne enciklopedije
CLSPN
Identifikatori
AliasiCLSPN
Vanjski ID-jeviOMIM: 605434 MGI: 2445153 HomoloGene: 11138 GeneCards: CLSPN
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za CLSPN
Genomska lokacija za CLSPN
Bend1p34.3Početak35,720,218 bp[1]
Kraj35,769,978 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za CLSPN
Genomska lokacija za CLSPN
Bend4|4 D2.2Početak126,450,728 bp[2]
Kraj126,487,696 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa DNK
GO:0001948, GO:0016582 vezivanje za proteine
anaphase-promoting complex binding
Ćelijska komponenta jedro
nukleoplazma
Golđijev aparat
Biološki proces Replikacija DNK
ćelijski ciklus
DNA damage checkpoint signaling
mitotic DNA replication checkpoint signaling
GO:0035404 peptidyl-serine phosphorylation
activation of protein kinase activity
cellular response to DNA damage stimulus
GO:0100026 Popravka DNK
protein deubiquitination
mitotic G2 DNA damage checkpoint signaling
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001190481
NM_022111
NM_001330490

NM_175554

RefSeq (bjelančevina)

NP_001177410
NP_001317419
NP_071394

NP_780763
NP_001392727
NP_001392728
NP_001392729
NP_001392730

Lokacija (UCSC)Chr 1: 35.72 – 35.77 MbChr 4: 126.45 – 126.49 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Klaspin jest protein koji je kod ljudi kodiran genom CLSPN sa hromosoma 1.[5][6][7]

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 1.339 aminokiselina, a molekulska težina 151.094 Da.[8]

1020304050
MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEI
FVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKI
KRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKS
SKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQ
PFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKK
EPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRES
ALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDT
ANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKD
LVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVA
FEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQL
GVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQT
VNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAK
LQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKV
EKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENN
DGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENS
GKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF
PTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPK
TLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMD
ENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTS
QDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGD
FRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRL
RKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKK
IHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMD
LFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEI
GEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQV
KTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESS
KSQVKKRGPSFMTSPSPKHLKTDDSTSGLTRSIFKYLES

Funkcija

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Klaspin u žaba roda Xenopus je esencijalni uzvodni regulator kinazne kontrolne tačke 1 i pokreće zaustavljanje kontrolne tačke ćelijskog ciklusa u prisustvu DNK šablona u ekstraktima ksenopusovih jaja. Čini se da je ljudski gen homolog njegovom klaspinu, a njegova funkcija još nije utvrđena.[7]

Interakcije

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Pokazalo se da CLSPN ima interakcije sa:

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092853 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042489 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kumagai A, Dunphy WG (Nov 2000). "Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts". Mol Cell. 6 (4): 839–49. doi:10.1016/S1097-2765(05)00092-4. PMID 11090622.
  6. ^ a b Chini CC, Chen J (Aug 2003). "Human claspin is required for replication checkpoint control". J Biol Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
  7. ^ a b "Entrez Gene: CLSPN claspin homolog (Xenopus laevis)".
  8. ^ "UniProt, Q9HAW4" (jezik: engleski). Pristupljeno 23. 11. 2021.
  9. ^ Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484–9. Bibcode:2004PNAS..101.6484L. doi:10.1073/pnas.0401847101. PMC 404071. PMID 15096610.
  10. ^ a b c Serçin O, Kemp MG (maj 2011). "Characterization of functional domains in human Claspin". Cell Cycle. 10 (10): 1599–606. doi:10.4161/cc.10.10.15562. PMC 3127160. PMID 21478680.
  11. ^ Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N (2009). "USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin". J. Cell Biol. 184 (1): 13–9. doi:10.1083/jcb.200807137. PMC 2615094. PMID 19124652.

Dopunska literatura

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Vanjski linkovi

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