•
Publication Date: 2007
Publication Name: Pharos XIV (2006)
•
Publisher: Elsevier
Publication Date: Jan 1, 2010
Publication Name: Journal of Biomedical …
Research Interests: Algorithms, Computational Biology, Biomedical informatics, Biomedical, Protein synthesis, and 18 moreArabidopsis thaliana, Feature Selection, Biological Sciences, Software, Decision Trees, Performance Evaluation, Humans, Computer Model, Alternative splicing, Support vector machine, ROC Curve, Arabidopsis, Prediction Model, Source Code, Alternative Splicing, Normal Distribution, Hybrid Method, and Probabilistic Model
•
Epigenetic changes include the addition of a methyl group to the 5' carbon of the cytosine ring, known as DNA methylation, which results in the generation of the fifth DNA base, namely 5-methylcytosine. During... more
Epigenetic changes include the addition of a methyl group to the 5' carbon of the cytosine ring, known as DNA methylation, which results in the generation of the fifth DNA base, namely 5-methylcytosine. During active or passive demethylation, an intermediate modified base is formed, 5-hydroxymethylcytosine. We have currently quantified 5-methylcytosine and 5-hydroxymethylcytosine in the liver and brain of mice treated with cocaine or heroin, using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Our results show that global 5-methylcytosine levels are not affected by heroin or cocaine administration, neither in the liver nor in the brain. However, 5-hydroxymethylcytosine levels are reduced in the liver following cocaine administration, while they are not affected by cocaine in the brain or by heroin administration in the liver and the brain. Elucidation of the epigenetic phenomena that takes place with respect to drug abuse and addiction, via quantitative analysis of different modified bases, may enable a better understanding of the underlying mechanisms and may lead to more personalized and effective treatment options.
Publication Date: 2014
Publication Name: Toxicology Letters
Research Interests:
•
by G. Tzimagiorgis and Sofia Kouidou
Publication Date: 2011
Publication Name: Cancer Epidemiology
Research Interests:
•
Publication Date: 2010
Publication Name: Journal of Clinical Virology
Research Interests:
•
Publication Date: 1998
Publication Name: AIDS Research and Human Retroviruses
Research Interests:
•