ROCK2

ROCK2
بنى متوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 4L6Q, 4WOT
معرفات
أسماء بديلة	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604002 MGI: MGI:107926 HomoloGene: 21010 GeneCards: 9475
علم الوجود الجيني وظائف جزيئية • نشاط انتقالي • nucleotide binding • protein kinase activity • structural molecule activity • ربط أيون فلزي • kinase activity • protein serine/threonine kinase activity • ‏GO:0001948، ‏GO:0016582 ربط بروتيني • ATP binding • Rho-dependent protein serine/threonine kinase activity • RNA binding • tau protein binding • tau-protein kinase activity مكونات خلوية • سيتوبلازم • جسيم مركزي • غشاء • غشاء خلوي • مركز تنظيم الأنيبيبات الدقيقة • حبيبة رنا • هيكل خلوي • نواة • عصارة خلوية • داخل خلوي عمليات حيوية • smooth muscle contraction • positive regulation of protein phosphorylation • ‏GO:0007243 intracellular signal transduction • regulation of actin cytoskeleton organization • centrosome duplication • فسفرة • عملية إيقاعية • ephrin receptor signaling pathway • cellular response to testosterone stimulus • انقسام السيتوبلازم • positive regulation of centrosome duplication • regulation of stress fiber assembly • regulation of cell motility • positive regulation of endothelial cell migration • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • ‏GO:1901313 positive regulation of gene expression • regulation of cell adhesion • regulation of circadian rhythm • Rho protein signal transduction • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • ‏GO:0033109 cortical actin cytoskeleton organization • regulation of establishment of endothelial barrier • actin cytoskeleton organization • protein localization to plasma membrane • G protein-coupled receptor signaling pathway • aortic valve morphogenesis • positive regulation of cardiac muscle hypertrophy • ‏GO:0035404 peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • positive regulation of cell migration • positive regulation of connective tissue growth factor production • positive regulation of MAPK cascade • regulation of protein metabolic process • positive regulation of stress fiber assembly • negative regulation of biomineral tissue development • response to transforming growth factor beta • positive regulation of fibroblast growth factor production • regulation of angiotensin-activated signaling pathway • negative regulation of protein localization to lysosome • positive regulation of amyloid-beta formation • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • positive regulation of protein localization to early endosome • positive regulation of amyloid precursor protein catabolic process • positive regulation of connective tissue replacement • response to angiotensin • response to ischemia • negative regulation of gene expression • regulation of nervous system process • negative regulation of nitric oxide biosynthetic process • mRNA destabilization • blood vessel diameter maintenance • regulation of cellular response to hypoxia • cellular response to acetylcholine • mitotic cytokinesis • actomyosin structure organization • embryonic morphogenesis • regulation of cell junction assembly المصادر:Amigo / QuickGO
تماثلات متسلسلة
أنواع	الإنسان	الفأر
أنتريه	9475	19878
Ensembl	ENSG00000134318	ENSMUSG00000020580
يونيبروت	O75116 C9JFJ0	P70336
RefSeq (رنا مرسال.)	‏NM_004850، ‏XM_005246190، ‏NM_001321643، ‏XM_017005378، ‏XM_017005379 XM_011510417، ‏NM_004850، ‏XM_005246190، ‏NM_001321643، ‏XM_017005378، ‏XM_017005379	‏XM_006515019، ‏XM_006515020 NM_009072، ‏XM_006515019، ‏XM_006515020
RefSeq (بروتين)	‏NP_004841، ‏XP_005246247، ‏XP_011508719، ‏XP_016860867، ‏XP_016860868 NP_001308572، ‏NP_004841، ‏XP_005246247، ‏XP_011508719، ‏XP_016860867، ‏XP_016860868	‏XP_036013163، ‏XP_036013164، ‏XP_036013165، ‏XP_036013166، ‏XP_036013167، ‏XP_036013168 NP_033098، ‏XP_036013163، ‏XP_036013164، ‏XP_036013165، ‏XP_036013166، ‏XP_036013167، ‏XP_036013168
الموقع (UCSC	n/a	Chr 12: 16.89 – 16.99 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

ROCK2‏ (Rho associated coiled-coil containing protein kinase 2) هوَ بروتين يُشَفر بواسطة جين ROCK2 في الإنسان.

قراءة متعمقة

• Trauger JW، Lin FF، Turner MS، Stephens J، LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. ج. 41 ع. 28: 8948–53. DOI:10.1021/bi0258243. PMID:12102637.