Vedia Gedik
Ankara University, Endocrinology and metabolic diseases, Faculty Member
The discordance between insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels is an important problem in the follow-up of patients diagnosed with acromegaly. Our aims were to evaluate the discordance between IGF-1 and GH... more
The discordance between insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels is an important problem in the follow-up of patients diagnosed with acromegaly. Our aims were to evaluate the discordance between IGF-1 and GH levels and to compare the performance of different cut-off levels for the nadir in GH (GHn) in acromegalic patients. The study included 63 acromegalic patients in a follow-up at a tertiary care university hospital facility. The IGF-1, IGF binding protein-3 (IGFBP-3), and GH levels of the subjects were investigated. The baseline GH and GHn levels were evaluated after an oral glucose tolerance test (cut-off for both 0.4 ng/ml and 1 ng/ml). The discordance rates between GHn and IGF-1 levels, and IGF-1/IGFBP-3 ratios were determined. We first adopted a GHn cut-off value of 1 ng/ml and found that 27 patients (42.9%) exhibited biochemical remission (BR) (IGF-1<95(th) percentile, GH<1), and 25 patients (39.7%) had no BR (NBR) (IGF-1 ≥95(th) percentile, ...
Research Interests:
Research Interests:
Research Interests:
Nöropati, en sık görülen diyabetik mikrovasküler komplikasyondur. En sık rastlanan nöropati ise, periferik sensorimotor polinöropatidir. İlk olarak distal alt ekstremiteleri etkiler. Hastalığın ilerlemesi ile duyusal kayıp proksimale... more
Nöropati, en sık görülen diyabetik mikrovasküler komplikasyondur. En sık rastlanan nöropati ise, periferik sensorimotor polinöropatidir. İlk olarak distal alt ekstremiteleri etkiler. Hastalığın ilerlemesi ile duyusal kayıp proksimale doğru çıkar ve ellerde de başlar. Tipik olarak ...