三氯卡班
外观
三氯卡班 | |
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IUPAC名 3-(4-Chlorophenyl)-1-(3,4-dichlorophenyl)urea | |
别名 | Trichlorocarbanilide, TCC, Solubacter |
识别 | |
CAS号 | 101-20-2 ![]() |
PubChem | 7547 |
ChemSpider | 7266 |
SMILES |
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InChI |
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InChIKey | ICUTUKXCWQYESQ-UHFFFAOYAL |
ChEBI | 48347 |
性质 | |
化学式 | C13H9Cl3N2O |
摩尔质量 | 315.58 g·mol−1 |
密度 | 1.53 g/cm3 |
熔点 | 254—256 °C(527—529 K) |
危险性 | |
NFPA 704 | |
闪点 | > |
致死量或浓度: | |
LD50(中位剂量)
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>5000 mg/kg(小鼠,口)[1] 2100 mg/kg(小鼠,腹腔注射)[1] |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
三氯卡班(英語:Triclocarban,缩写TCC)是一种抗细菌化学物质,最初用于医药,后来用于肥皂和洗手液,但现在已不再常用[2]。TCC能有效抑制金黄色葡萄球菌(Staphylococcus aureus)的生长,但其作用机理尚不明确[3],TCC已产生了一些耐药性和环境污染,也会扰乱内分泌[4]。
另见
[编辑]- 二氯苯氧氯酚(又名三氯生)
参考文献
[编辑]- ^ 1.0 1.1 Marty, J. P.; Wepierre, J. Toxicity evaluation of cosmetically active substances: case of trichlorocarbanilide. Labo-Pharma - Problemes et Techniques. 1979, 27 (286): 306–10.
- ^ "Anti-bacterial personal hygiene products may not be worth potential risks." UC Davis Health System Feature Story: Anti-bacterial personal hygiene products.... UC Davis Health System, n.d. Web. 12 Mar. 2014. <http://www.ucdmc.ucdavis.edu/welcome/features/20080903_anti-bacterial/ (页面存档备份,存于互联网档案馆)>
- ^ Walsh, S. E.; Maillard, J.-Y.; Russell, A. D.; Catrenich, C. E.; Charbonneau, D. L.; Bartolo, R. G. Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. Journal of Applied Microbiology. 2003, 94 (2): 240–247. ISSN 1364-5072. PMID 12534815. doi:10.1046/j.1365-2672.2003.01825.x.
- ^ Rochester, Johanna R.; Bolden, Ashley L.; Pelch, Katherine E.; Kwiatkowski, Carol F. Potential Developmental and Reproductive Impacts of Triclocarban: A Scoping Review. Journal of Toxicology. 2017, 2017: 9679738. ISSN 1687-8191. PMC 5733165
. PMID 29333157. doi:10.1155/2017/9679738.
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