Bulletin of the Chemical Society of Ethiopia, 2021
ABSTRACT. A series of metal complexes [Co(HL)2(H2O)2]Cl2.5H2O (A), [Cu(HL)2](CH3COO)2.2H2O (B), [... more ABSTRACT. A series of metal complexes [Co(HL)2(H2O)2]Cl2.5H2O (A), [Cu(HL)2](CH3COO)2.2H2O (B), [Y(HL)2]Cl3.2H2O (C), [ZrO(HL)2H2O]Cl2.H2O (D), [La(HL)2(H2O)2]Cl3.5H2O (E) and [UO2(HL)2](CH3COO)2 (F) were prepared. The structures of the compounds in solid state were detected by micro analytical, Fourier transform IR, 1H NMR, UV-Vis, mass, X-ray diffraction spectra, molar conductivity, magnetic susceptibility measurements and TG/DTG analysis. The IR spectral data point out that the ligand behaves as tridentate in nature with Cu(II), Y(III), U(VI) and bidentate with Co(II), Zr(IV) and La(III) metal ions. The conductivity values showed that the complexes found as electrolytes and the XRD models of the complexes indicated crystalline nature. The thermodynamic parameters of compounds have been detected using Coats-Redfern and Horowitz-Metzeger methods at n = 1 and n ≠ 1 and values point out more ordered activated complex formation. The nematicidal efficacy of compounds was assessed. ...
Bulletin of the Chemical Society of Ethiopia, 2020
New series of Y(III), Zr(IV), Pd(II), La(III) and U(VI) complexes with moxifloxacin (MOX) and 1,1... more New series of Y(III), Zr(IV), Pd(II), La(III) and U(VI) complexes with moxifloxacin (MOX) and 1,10-phenanthroline (Phen) were synthesized and the chelation behaviours have been investigated. The complexes were characterized using elemental analysis, molar conductance, magnetic properties, thermal studies and various spectral techniques such as FT-IR, UV-Vis, 1H NMR and mass spectra. The kinetic and thermodynamic parameters (E*, ΔH*, ΔS* and ΔG*) were calculated using Coats-Redfern and Horowitz-Metzeger methods. The bond length and force constant, F(U=O), for the uranyl complex was calculated. The DFT calculations were carried out to understand the optimized molecular geometry for the compounds. The calculated data indicated that Pd(II) complex with smaller energy gap value (∆E = 0.136 au) is more reactive than all compounds and La(III) complex with greater energy gap (∆E = 0.192 au) is less reactive. All studied compounds are treated as soft (η = 0.068-0.096) except MOX treated as h...
Bulletin of the Chemical Society of Ethiopia, 2021
ABSTRACT. Cobalt(II), copper(II), yttrium(III), zirconium(IV), lanthanum(III) and uranium(VI) com... more ABSTRACT. Cobalt(II), copper(II), yttrium(III), zirconium(IV), lanthanum(III) and uranium(VI) complexes of 1,4-di(2-hydroxybenzylidene)thiosemicarbazide (H2L) were prepared and characterized. The proposed structures were determined from their elemental analyses, molar conductivities, magnetic moment, IR, Proton NMR, UV-Vis., mass spectra, X-ray diffraction and thermal analyses measurements. The high conductance data supply evidence for the electrolytic nature of the complexes. The changes in the selected bands in IR of Schiff base ligand upon coordination showed that Schiff base exhibits as a neutral tetradentate manner with oxygen and nitrogen donor sites. The complexes are thermally steady at room temperature and break up to two or three steps. The kinetic and thermodynamic parameters of complexes have been determined by using Coats-Redfern and Horowitz-Metzeger methods at n=1 and n≠1 and values suggest more ordered activated complex formation. The calculated bond length and force...
Abstract The Preparation and characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Y(I... more Abstract The Preparation and characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Y(III) mixed ligand metal complexes with the effective anti-inflammatory drug tenoxicam (Ten) and 2,2′-bipyridine (Bipy) have been informed in this study by using elemental analyses, FT-IR, UV–Vis., 1H NMR, mass spectra, thermal analyses (TGA, DTG), molar conductance and magnetic moment. FT-IR and UV–Vis. spectra proved that Ten acts as a neutral bidentate ligand chelated to the metal ions via the pyridine-N and oxygen of carbonyl group of the amide moiety and Bipy chelated through the nitrogen atoms. The thermodynamic parameters (E*, ΔS∗, ΔH∗ and ΔG∗) were calculated by using Coats–Redfern and Horowitz– Metzger method from DTG curves. The antimicrobial activity for all compounds against various species of bacteria and fungi was investigated and the results ensured that Fe(III) complex is more active than all other complexes. The DFT calculations were carried out to understand the optimized molecular geometry for the compounds. All studied complexes considered as soft respect to the Ten, with σ value varied from 11.236 to 16.949 eV and equal to 8.772eV for Ten. The anticancer activity was screened against cell culture of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma) for all compounds.
Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2015
The coordination of CIP-en (N,N′- ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-... more The coordination of CIP-en (N,N′- ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-quinoline-3-carboxylic acid) towards Cr(III), Mn(II), Fe(III), Co(II), and Ni(II) ions has been investigated. The elemental analysis, melting point, molar conductivity, magnetic properties, infrared, UV-Vis, mass, 1H NMR spectra, and thermal analysis studies were used to characterize the complexes. TGA and DTG have been applied to study the compositions of the compounds. The measured molar conductance values indicate that the complexes are electrolytes in nature. The biological activities of the complexes were assayed against several bacterial strains.
[Zn(Ofl)(Phen)(H 2 O) 2 ](CH 3 COO)$2H 2 O (1), [ZrO(Ofl)(Phen)(H 2 O)]NO 3 $2H 2 O (2) and [UO 2... more [Zn(Ofl)(Phen)(H 2 O) 2 ](CH 3 COO)$2H 2 O (1), [ZrO(Ofl)(Phen)(H 2 O)]NO 3 $2H 2 O (2) and [UO 2 (Ofl)(Phen)-(H 2 O)](CH 3 COO)$H 2 O (3) complexes of fluoroquinolone antibacterial agent ofloxacin (HOfl), containing a nitrogen donor heterocyclic ligand, 1,10-phenathroline monohydrate (Phen), were prepared and their structures were established with the help of elemental analysis, molar conductance, magnetic properties, thermal studies and different spectroscopic studies like IR, UV-Vis., 1 H NMR and Mass. The IR data of HOfl and Phen ligands suggested the existing of a bidentate binding involving carboxylate O and pyridone O for HOfl ligand and two pyridine N atoms for Phen ligand. The coordination geometries and electronic structures are determined from electronic absorption spectra and magnetic moment measurements. From molar conductance studies reveals that metal complexes are electrolytes and of 1:1 type. The calculated bond length and force constant, F(U]O), in the uranyl complex are 1.751 Å and 641.04 Nm À1. The thermal properties of the complexes were investigated by thermogravimetry (TGA) technique. The activation thermodynamic parameters are calculated using CoatseRedfern and Horowitz-Metzger methods. Antimicrobial activity of the compounds was evaluated against some bacteria and fungi species. The activity data show that most metal complexes have antibacterial activity than that of the parent HOfl drug. The in vitro cytotoxicities of ligands and their complexes were also evaluated against human breast and colon carcinoma cells.
In this study, mixed ligand complexes derived
from gemifloxacin as primary ligand and 1,10-phenant... more In this study, mixed ligand complexes derived from gemifloxacin as primary ligand and 1,10-phenanthroline as secondary ligand have been prepared and characterized by conventional techniques including elemental analyses, infrared, electronic spectra, HNMR, mass and thermal analyses. The infrared spectral data show the chelation behavior of the ligands toward the metal ions through oxygen of pyridone, one oxygen of carboxylic group of gemifloxacin and pyridyl nitrogen of 1,10phenanthroline. Thermal analyses show that the complexes lose water molecules of hydration initially and subsequently expel coordinated water molecules and organic ligands in continuous steps. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.753 A ˚ and 636.33 Nm -1 , respectively. Also, the two ligands, in comparison with its metal complexes, are screened for their antimicrobial activity. Activity index data showed that La(III) is the highest activity and shows very highly significant against Bacillus subtilis compared with gemifloxacin. The anticancer activity was screened against breast cancer cell line and colon cancer cell line.
The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
Bulletin of the Chemical Society of Ethiopia, 2021
ABSTRACT. A series of metal complexes [Co(HL)2(H2O)2]Cl2.5H2O (A), [Cu(HL)2](CH3COO)2.2H2O (B), [... more ABSTRACT. A series of metal complexes [Co(HL)2(H2O)2]Cl2.5H2O (A), [Cu(HL)2](CH3COO)2.2H2O (B), [Y(HL)2]Cl3.2H2O (C), [ZrO(HL)2H2O]Cl2.H2O (D), [La(HL)2(H2O)2]Cl3.5H2O (E) and [UO2(HL)2](CH3COO)2 (F) were prepared. The structures of the compounds in solid state were detected by micro analytical, Fourier transform IR, 1H NMR, UV-Vis, mass, X-ray diffraction spectra, molar conductivity, magnetic susceptibility measurements and TG/DTG analysis. The IR spectral data point out that the ligand behaves as tridentate in nature with Cu(II), Y(III), U(VI) and bidentate with Co(II), Zr(IV) and La(III) metal ions. The conductivity values showed that the complexes found as electrolytes and the XRD models of the complexes indicated crystalline nature. The thermodynamic parameters of compounds have been detected using Coats-Redfern and Horowitz-Metzeger methods at n = 1 and n ≠ 1 and values point out more ordered activated complex formation. The nematicidal efficacy of compounds was assessed. ...
Bulletin of the Chemical Society of Ethiopia, 2020
New series of Y(III), Zr(IV), Pd(II), La(III) and U(VI) complexes with moxifloxacin (MOX) and 1,1... more New series of Y(III), Zr(IV), Pd(II), La(III) and U(VI) complexes with moxifloxacin (MOX) and 1,10-phenanthroline (Phen) were synthesized and the chelation behaviours have been investigated. The complexes were characterized using elemental analysis, molar conductance, magnetic properties, thermal studies and various spectral techniques such as FT-IR, UV-Vis, 1H NMR and mass spectra. The kinetic and thermodynamic parameters (E*, ΔH*, ΔS* and ΔG*) were calculated using Coats-Redfern and Horowitz-Metzeger methods. The bond length and force constant, F(U=O), for the uranyl complex was calculated. The DFT calculations were carried out to understand the optimized molecular geometry for the compounds. The calculated data indicated that Pd(II) complex with smaller energy gap value (∆E = 0.136 au) is more reactive than all compounds and La(III) complex with greater energy gap (∆E = 0.192 au) is less reactive. All studied compounds are treated as soft (η = 0.068-0.096) except MOX treated as h...
Bulletin of the Chemical Society of Ethiopia, 2021
ABSTRACT. Cobalt(II), copper(II), yttrium(III), zirconium(IV), lanthanum(III) and uranium(VI) com... more ABSTRACT. Cobalt(II), copper(II), yttrium(III), zirconium(IV), lanthanum(III) and uranium(VI) complexes of 1,4-di(2-hydroxybenzylidene)thiosemicarbazide (H2L) were prepared and characterized. The proposed structures were determined from their elemental analyses, molar conductivities, magnetic moment, IR, Proton NMR, UV-Vis., mass spectra, X-ray diffraction and thermal analyses measurements. The high conductance data supply evidence for the electrolytic nature of the complexes. The changes in the selected bands in IR of Schiff base ligand upon coordination showed that Schiff base exhibits as a neutral tetradentate manner with oxygen and nitrogen donor sites. The complexes are thermally steady at room temperature and break up to two or three steps. The kinetic and thermodynamic parameters of complexes have been determined by using Coats-Redfern and Horowitz-Metzeger methods at n=1 and n≠1 and values suggest more ordered activated complex formation. The calculated bond length and force...
Abstract The Preparation and characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Y(I... more Abstract The Preparation and characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Y(III) mixed ligand metal complexes with the effective anti-inflammatory drug tenoxicam (Ten) and 2,2′-bipyridine (Bipy) have been informed in this study by using elemental analyses, FT-IR, UV–Vis., 1H NMR, mass spectra, thermal analyses (TGA, DTG), molar conductance and magnetic moment. FT-IR and UV–Vis. spectra proved that Ten acts as a neutral bidentate ligand chelated to the metal ions via the pyridine-N and oxygen of carbonyl group of the amide moiety and Bipy chelated through the nitrogen atoms. The thermodynamic parameters (E*, ΔS∗, ΔH∗ and ΔG∗) were calculated by using Coats–Redfern and Horowitz– Metzger method from DTG curves. The antimicrobial activity for all compounds against various species of bacteria and fungi was investigated and the results ensured that Fe(III) complex is more active than all other complexes. The DFT calculations were carried out to understand the optimized molecular geometry for the compounds. All studied complexes considered as soft respect to the Ten, with σ value varied from 11.236 to 16.949 eV and equal to 8.772eV for Ten. The anticancer activity was screened against cell culture of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma) for all compounds.
Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2015
The coordination of CIP-en (N,N′- ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-... more The coordination of CIP-en (N,N′- ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-quinoline-3-carboxylic acid) towards Cr(III), Mn(II), Fe(III), Co(II), and Ni(II) ions has been investigated. The elemental analysis, melting point, molar conductivity, magnetic properties, infrared, UV-Vis, mass, 1H NMR spectra, and thermal analysis studies were used to characterize the complexes. TGA and DTG have been applied to study the compositions of the compounds. The measured molar conductance values indicate that the complexes are electrolytes in nature. The biological activities of the complexes were assayed against several bacterial strains.
[Zn(Ofl)(Phen)(H 2 O) 2 ](CH 3 COO)$2H 2 O (1), [ZrO(Ofl)(Phen)(H 2 O)]NO 3 $2H 2 O (2) and [UO 2... more [Zn(Ofl)(Phen)(H 2 O) 2 ](CH 3 COO)$2H 2 O (1), [ZrO(Ofl)(Phen)(H 2 O)]NO 3 $2H 2 O (2) and [UO 2 (Ofl)(Phen)-(H 2 O)](CH 3 COO)$H 2 O (3) complexes of fluoroquinolone antibacterial agent ofloxacin (HOfl), containing a nitrogen donor heterocyclic ligand, 1,10-phenathroline monohydrate (Phen), were prepared and their structures were established with the help of elemental analysis, molar conductance, magnetic properties, thermal studies and different spectroscopic studies like IR, UV-Vis., 1 H NMR and Mass. The IR data of HOfl and Phen ligands suggested the existing of a bidentate binding involving carboxylate O and pyridone O for HOfl ligand and two pyridine N atoms for Phen ligand. The coordination geometries and electronic structures are determined from electronic absorption spectra and magnetic moment measurements. From molar conductance studies reveals that metal complexes are electrolytes and of 1:1 type. The calculated bond length and force constant, F(U]O), in the uranyl complex are 1.751 Å and 641.04 Nm À1. The thermal properties of the complexes were investigated by thermogravimetry (TGA) technique. The activation thermodynamic parameters are calculated using CoatseRedfern and Horowitz-Metzger methods. Antimicrobial activity of the compounds was evaluated against some bacteria and fungi species. The activity data show that most metal complexes have antibacterial activity than that of the parent HOfl drug. The in vitro cytotoxicities of ligands and their complexes were also evaluated against human breast and colon carcinoma cells.
In this study, mixed ligand complexes derived
from gemifloxacin as primary ligand and 1,10-phenant... more In this study, mixed ligand complexes derived from gemifloxacin as primary ligand and 1,10-phenanthroline as secondary ligand have been prepared and characterized by conventional techniques including elemental analyses, infrared, electronic spectra, HNMR, mass and thermal analyses. The infrared spectral data show the chelation behavior of the ligands toward the metal ions through oxygen of pyridone, one oxygen of carboxylic group of gemifloxacin and pyridyl nitrogen of 1,10phenanthroline. Thermal analyses show that the complexes lose water molecules of hydration initially and subsequently expel coordinated water molecules and organic ligands in continuous steps. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.753 A ˚ and 636.33 Nm -1 , respectively. Also, the two ligands, in comparison with its metal complexes, are screened for their antimicrobial activity. Activity index data showed that La(III) is the highest activity and shows very highly significant against Bacillus subtilis compared with gemifloxacin. The anticancer activity was screened against breast cancer cell line and colon cancer cell line.
The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
Uploads
from gemifloxacin as primary ligand and 1,10-phenanthroline
as secondary ligand have been prepared and
characterized by conventional techniques including elemental
analyses, infrared, electronic spectra,
HNMR,
mass and thermal analyses. The infrared spectral data show
the chelation behavior of the ligands toward the metal ions
through oxygen of pyridone, one oxygen of carboxylic
group of gemifloxacin and pyridyl nitrogen of 1,10phenanthroline.
Thermal analyses show that the complexes
lose water molecules of hydration initially and subsequently
expel coordinated water molecules and organic
ligands in continuous steps. The calculated bond length and
force constant, F(U=O), in the uranyl complex are 1.753 A
˚
and 636.33 Nm
-1
, respectively. Also, the two ligands, in
comparison with its metal complexes, are screened for their
antimicrobial activity. Activity index data showed that
La(III) is the highest activity and shows very highly significant
against Bacillus subtilis compared with gemifloxacin.
The anticancer activity was screened against
breast cancer cell line and colon cancer cell line.
from gemifloxacin as primary ligand and 1,10-phenanthroline
as secondary ligand have been prepared and
characterized by conventional techniques including elemental
analyses, infrared, electronic spectra,
HNMR,
mass and thermal analyses. The infrared spectral data show
the chelation behavior of the ligands toward the metal ions
through oxygen of pyridone, one oxygen of carboxylic
group of gemifloxacin and pyridyl nitrogen of 1,10phenanthroline.
Thermal analyses show that the complexes
lose water molecules of hydration initially and subsequently
expel coordinated water molecules and organic
ligands in continuous steps. The calculated bond length and
force constant, F(U=O), in the uranyl complex are 1.753 A
˚
and 636.33 Nm
-1
, respectively. Also, the two ligands, in
comparison with its metal complexes, are screened for their
antimicrobial activity. Activity index data showed that
La(III) is the highest activity and shows very highly significant
against Bacillus subtilis compared with gemifloxacin.
The anticancer activity was screened against
breast cancer cell line and colon cancer cell line.