Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2024; 16(7): 1067-1069
Published online Jul 27, 2024. doi: 10.4254/wjh.v16.i7.1067
Acute liver failure: A clinically severe syndrome characterized by intricate mechanisms
Ran An, Jing-Lin Wang
Ran An, Jing-Lin Wang, Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China
Author contributions: An R is responsible for writing this letter; Wang JL revised the letter.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Lin Wang, Doctor, Associate Professor, Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. cw20120817@163.com
Received: April 22, 2024
Revised: May 26, 2024
Accepted: June 14, 2024
Published online: July 27, 2024
Processing time: 95 Days and 8.5 Hours
Abstract

Acute liver failure presents as a clinical syndrome characterized by swift deterioration and significant mortality rates. Its underlying mechanisms are intricate, involving intricate interplays between various cells. Given the current scarcity of treatment options, there's a pressing need to diligently uncover the disease's core mechanisms and administer targeted therapies accordingly.

Keywords: Acute liver failure; Hepatocyte; Macrophage; Necroptosis; Pyroptosis; Ferroptosis

Core Tip: Acute Liver Failure (ALF) is a clinical syndrome characterized by a complex pathogenesis and a high mortality rate. The core mechanism that triggers ALF has been shown to be the imbalance of the immune microenvironment. The functions of the immune system during liver injury are diverse, encompassing both the early clearance of damaging substances and later tissue repair. However, achieving a smooth transition between these functions and avoiding the aggravation of liver injury caused by excessive activation or suppression of the immune system is a current research hotspot.