N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor (Q90381630)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31569395%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

title

N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor (English)

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13 April 2020

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13 April 2020

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13 April 2020

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13 April 2020

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13 April 2020

Michele Vasaturo

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13 April 2020

Fabrizio Dal Piaz

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13 April 2020

Bruno Marcello Fusco

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13 April 2020

Cristina Pagano

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13 April 2020

Chiara Laezza

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13 April 2020

Maurizio Bifulco

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13 April 2020

publication date

28 September 2019

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13 April 2020

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13 April 2020

volume

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13 April 2020

issue

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Creative Commons Attribution 4.0 International

13 April 2020

start time

28 September 2019

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April 2022 Public Data File from Crossref

copyrighted

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cites work

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

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12 December 2020

N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

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12 December 2020

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

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Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

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N6-isopentenyladenosine: a potential therapeutic agent for a variety of epithelial cancers

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Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level

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Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug

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12 December 2020

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

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12 December 2020

N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1.

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12 December 2020

Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine

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Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance

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12 December 2020

Drug combination studies and their synergy quantification using the Chou-Talalay method

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12 December 2020

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

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12 December 2020

Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer

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Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

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12 December 2020

Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth.

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12 December 2020

Antiproliferative activity of N(6)-isopentenyladenosine on HCT-15 colon carcinoma cell line.

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12 December 2020

Pharmacological actions of statins: a critical appraisal in the management of cancer

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Role of the ubiquitin ligase Fbw7 in cancer progression

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Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer

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12 December 2020

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

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12 December 2020

Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells.

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12 December 2020

Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation.

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12 December 2020

Mevalonate metabolism in cancer

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12 December 2020

Histone H2B monoubiquitination: roles to play in human malignancy

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12 December 2020

Structural Evidence of N6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

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12 December 2020

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities

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12 December 2020

SCF ubiquitin ligase-targeted therapies.

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12 December 2020

Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma

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12 December 2020

FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

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12 December 2020

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

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12 December 2020

MED23: a new Mediator of H2B monoubiquitylation

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12 December 2020

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

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12 December 2020

Types of Ubiquitin Ligases

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12 December 2020

Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture

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12 December 2020

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.

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Cullin-RING ligases in regulation of autophagy

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12 December 2020

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

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FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

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12 December 2020

27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells

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12 December 2020

Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor.

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12 December 2020

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

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Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy

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12 December 2020

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells.

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12 December 2020

Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non-Small Cell Lung Cancer.

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12 December 2020

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

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12 December 2020

MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.

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12 December 2020

Recognition by natural killer cells of N6-isopentenyladenosine-treated human glioma cell lines

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12 December 2020

Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.

1 reference

12 December 2020

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ.

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12 December 2020

Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer

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12 December 2020

N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux

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12 December 2020

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma.

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12 December 2020

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

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12 December 2020

Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids

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12 December 2020

FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells.

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12 December 2020

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer

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12 December 2020

Cholesterol promotes the migration and invasion of renal carcinoma cells by regulating the KLF5/miR-27a/FBXW7 pathway

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12 December 2020

Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells

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12 December 2020

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

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12 December 2020

Identifiers

DOI

10.3390/CANCERS11101456

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31569395%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31569395%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

PubMed publication ID

31569395

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31569395%20AND%20SRC:MED&resulttype=core&format=json