Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma (Q90197653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

title

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

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12 April 2020

M Hope Robinson

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Victor Maximov

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Shoeb Lallani

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Hamza Farooq

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Michael D Taylor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Renee D Read

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12 April 2020

publication date

20 September 2019

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12 April 2020

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12 April 2020

volume

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issue

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12 April 2020

page(s)

13611

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

12 April 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6754407/fullTextXML

inferred from PubMed Central ID database lookup

DESeq2

object named as

DESeq

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Subtypes of medulloblastoma have distinct developmental origins

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Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

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N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

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7 January 2021

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

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7 January 2021

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

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Hedgehog beyond medulloblastoma and basal cell carcinoma

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7 January 2021

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

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7 January 2021

YAP regulates neural progenitor cell number via the TEA domain transcription factor

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7 January 2021

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

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7 January 2021

The Hippo in the room: a new look at a key pathway in cell growth and transformation

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7 January 2021

Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

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7 January 2021

TEAD mediates YAP-dependent gene induction and growth control

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7 January 2021

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

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7 January 2021

An epigenetic gateway to brain tumor cell identity

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7 January 2021

The landscape of genomic alterations across childhood cancers.

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7 January 2021

Epigenetic Drivers in Pediatric Medulloblastoma

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7 January 2021

Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics

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7 January 2021

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7 January 2021

The ghosts in the machine: DNA methylation and the mystery of differentiation

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7 January 2021

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

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7 January 2021

LSH cooperates with DNA methyltransferases to repress transcription

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7 January 2021

An SNF2 factor involved in mammalian development and cellular proliferation

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7 January 2021

LSH and G9a/GLP complex are required for developmentally programmed DNA methylation

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7 January 2021

Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

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7 January 2021

Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression

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7 January 2021

Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways

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7 January 2021

Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts

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7 January 2021

Cell cycle regulation of human DNA repair and chromatin remodeling genes

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7 January 2021

Lsh, a member of the SNF2 family, is required for genome-wide methylation

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7 January 2021

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

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7 January 2021

Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells

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7 January 2021

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7 January 2021

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7 January 2021

Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas

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7 January 2021

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7 January 2021

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

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7 January 2021

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7 January 2021

Genes involved in cerebellar cell specification and differentiation

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7 January 2021

SHH pathway and cerebellar development

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7 January 2021

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

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7 January 2021

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

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7 January 2021

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

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7 January 2021

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

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7 January 2021

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.

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7 January 2021

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

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7 January 2021

Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

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7 January 2021

Verteporfin, a suppressor of YAP-TEAD complex, presents promising antitumor properties on ovarian cancer

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7 January 2021

Verteporfin inhibits growth of human glioma in vitro without light activation

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7 January 2021

Medulloblastoma growth inhibition by hedgehog pathway blockade

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7 January 2021

Targeting epigenetic regulations in cancer

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7 January 2021

Lsh controls silencing of the imprinted Cdkn1c gene

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7 January 2021

Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.

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7 January 2021

Lsh controls Hox gene silencing during development

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7 January 2021

The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

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7 January 2021

Lsh, a SNF2 family member, is required for normal murine development

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7 January 2021

Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome

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7 January 2021

Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer

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7 January 2021

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Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma.

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7 January 2021

Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.

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7 January 2021

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation

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7 January 2021

Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis

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7 January 2021

DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.

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Evasion of Cell Senescence Leads to Medulloblastoma Progression

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

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7 January 2021

Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

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7 January 2021

Sonic hedgehog regulates the growth and patterning of the cerebellum

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PubMed

https://pubmed.ncbi.nlm.nih.gov/31541170

12 December 2020

inferred from PubMed ID database lookup

Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/31541170

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41598-019-50088-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

31541170

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541170%20AND%20SRC:MED&resulttype=core&format=json