BLM RecQ like helicase (Q885306)

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mammalian protein found in Homo sapiens
  • Bloom syndrome RecQ like helicase
  • Bloom syndrome, RecQ helicase-like
  • BLM
  • RecQ2
  • Bloom syndrome protein
  • recQ protein-like 3
  • DNA helicase, RecQ-like type 2
edit
Language Label Description Also known as
English
BLM RecQ like helicase
mammalian protein found in Homo sapiens
  • Bloom syndrome RecQ like helicase
  • Bloom syndrome, RecQ helicase-like
  • BLM
  • RecQ2
  • Bloom syndrome protein
  • recQ protein-like 3
  • DNA helicase, RecQ-like type 2

Statements

part of
molecular function
helicase activity
determination method or standard
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
9 May 2019
stated in
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
9 May 2019
stated in
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
protein binding
determination method or standard
IPI
24 references
retrieved
9 May 2019
stated in
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation and localization of the Bloom syndrome protein in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
hSSB1 associates with and promotes stability of the BLM helicase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
retrieved
9 May 2019
stated in
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IPI
ATP binding
determination method or standard
IBA
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
1 January 2018
stated in
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
1 January 2018
stated in
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
1 January 2018
stated in
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IBA
four-way junction helicase activity
determination method or standard
IBA
IDA
5 references
retrieved
9 May 2019
stated in
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IBA
cell component
nucleus
determination method or standard
IBA
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IEA
retrieved
9 May 2019
stated in
BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1
GOA
curator
UniProt
UniProt protein ID
P54132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132
determination method or standard
IBA
biological process

Identifiers

MeSH descriptor ID
C097151
subject named as
Bloom syndrome protein
0 references
Freebase ID
/m/03d011p
0 references
 
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