Bioreductively-activated prodrugs for targeting hypoxic tissues: elimination of aspirin from 2-nitroimidazole derivatives (Q77788021)

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8 December 2019

title

Bioreductively-activated prodrugs for targeting hypoxic tissues: elimination of aspirin from 2-nitroimidazole derivatives (English)

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8 December 2019

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S A Everett

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8 December 2019

M A Naylor

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8 December 2019

K B Patel

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8 December 2019

M R Stratford

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8 December 2019

P Wardman

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8 December 2019

publication date

1 May 1999

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Bioorganic & Medicinal Chemistry Letters

8 December 2019

published in

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8 December 2019

volume

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8 December 2019

issue

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8 December 2019

page(s)

1267-1272

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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

8 December 2019

cites work

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7 January 2021

Bioreductive therapies: an overview of drugs and their mechanisms of action

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Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine

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7 January 2021

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones

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7 January 2021

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

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7 January 2021

Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins showing very high in vitro selectivity

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7 January 2021

Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation

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7 January 2021

Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells

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7 January 2021

TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction

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7 January 2021

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide].

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7 January 2021

Measuring Tumor Hypoxia

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7 January 2021

New 5-substituted 1-alkyl-2-nitroimidazoles

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7 January 2021

The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles

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7 January 2021

Reduction of nitroimidazoles in model chemical and biological systems

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7 January 2021

Mechanism of the selective hypoxic cytotoxicity of 1-methyl-2-nitroimidazole

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7 January 2021

Oxidative stress and 1-methyl-2-nitroimidazole cytotoxicity.

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7 January 2021

A review of hypoxic cell radiosensitization.

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7 January 2021

Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) Radiation Therapy Oncology Group 83-03

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7 January 2021

The combination of multiple doses of etanidazole and pimonidazole in 48 patients: a toxicity and pharmacokinetic study

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7 January 2021

10.1016/S0960-894X(99)00171-7

Identifiers

DOI

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8 December 2019

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