Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2 (Q72827465)

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29 October 2019

review article

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title

Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7969108%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

M J Clemens

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29 October 2019

publication date

1 May 1994

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Molecular Biology Reports

29 October 2019

published in

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29 October 2019

volume

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29 October 2019

issue

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29 October 2019

page(s)

201-210

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Selection of the 5'-proximal translation initiation site is influenced by mRNA and eIF-2 concentrations

29 October 2019

cites work

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12 December 2020

Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits

1 reference

12 December 2020

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae

1 reference

12 December 2020

Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation

1 reference

12 December 2020

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1 reference

12 December 2020

Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes

1 reference

12 December 2020

Does protein phosphorylation play a role in translational control by eukaryotic aminoacyl-tRNA synthetases?

1 reference

12 December 2020

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1 reference

12 December 2020

The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.

1 reference

12 December 2020

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

12 December 2020

Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates

1 reference

12 December 2020

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation

1 reference

12 December 2020

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1 reference

12 December 2020

Autophosphorylation of the protein kinase dependent on double-stranded RNA

1 reference

12 December 2020

A novel role for aminoacyl-tRNA synthetases in the regulation of polypeptide chain initiation

1 reference

12 December 2020

Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor

1 reference

12 December 2020

The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2

1 reference

12 December 2020

Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells

1 reference

12 December 2020

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine

1 reference

12 December 2020

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase

1 reference

12 December 2020

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis

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12 December 2020

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae

1 reference

12 December 2020

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells

1 reference

12 December 2020

Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region

1 reference

12 December 2020

Purification of eukaryotic initiation factors eIF-2, eIF-2B and eIF-2 alpha kinase from bovine liver

1 reference

12 December 2020

Regulation of heme-controlled eukaryotic polypeptide chain initiation factor 2 alpha-subunit kinase of reticulocyte lysates

1 reference

12 December 2020

Regulation of polypeptide chain initiation in Chinese hamster ovary cells with a temperature-sensitive leucyl-tRNA synthetase. Changes in phosphorylation of initiation factor eIF-2 and in the activity of the guanine nucleotide exchange factor GEF

1 reference

12 December 2020

Tumorigenesis. Suppression with a difference.

1 reference

12 December 2020

Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase

1 reference

12 December 2020

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

1 reference

12 December 2020

Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells

1 reference

12 December 2020

Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase

1 reference

12 December 2020

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

1 reference

12 December 2020

Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.

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12 December 2020

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2

1 reference

12 December 2020

Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor

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12 December 2020

Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

1 reference

12 December 2020

Inhibitor of Interferon-Induced Double-Stranded RNA- Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli

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12 December 2020

Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats

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12 December 2020

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.

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12 December 2020

Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process

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12 December 2020

Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein

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12 December 2020

Regulation of translation initiation and modulation of cellular physiology

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12 December 2020

Interactions between double-stranded RNA regulators and the protein kinase DAI

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12 December 2020

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

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12 December 2020

A conserved double-stranded RNA-binding domain

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12 December 2020

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

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12 December 2020

Frog virus 3-induced translational shut-off: activation of an eIF-2 kinase in virus-infected cells

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12 December 2020

cis-acting sequences involved in the translational control of GCN4 expression

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12 December 2020

Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation

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12 December 2020

2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C.

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12 December 2020

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts

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12 December 2020

Chromosomal Assignment of the Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase (PRKR) to Human Chromosome 2p21-p22 and Mouse Chromosome 17 E2

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12 December 2020

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

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12 December 2020

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells

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12 December 2020

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

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12 December 2020

Localization of the Human Interferon-Induced, ds-RNA Activated p68 Kinase Gene (PRKR) to Chromosome 2p21-p22

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12 December 2020

Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells.

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12 December 2020

Adenovirus virus-associated RNA and translation control

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12 December 2020

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase

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12 December 2020

The war against the interferon-induced dsRNA-activated protein kinase: can viruses win?

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12 December 2020

Regulation of protein synthesis by phosphorylation of eukaryotic initiation factor 2 alpha in intact reticulocytes and reticulocyte lysates

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12 December 2020

Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells

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12 December 2020

Protein Phosphorylation in Translational Control

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12 December 2020

Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle

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12 December 2020

Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase

1 reference

12 December 2020

Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA

1 reference

12 December 2020

The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNAdependent, interferon-induced protein kinase, PKR

1 reference

12 December 2020

Initiation of protein synthesis in mammalian cells

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12 December 2020

Viroid-induced phosphorylation of a host protein related to a dsRNA-dependent protein kinase.

1 reference

12 December 2020

Translational activation of GCN4 mRNA in a cell-free system is triggered by uncharged tRNAs

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12 December 2020

Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI.

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12 December 2020

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA

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12 December 2020

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1 reference

12 December 2020

Reversal of the double-stranded-RNA-induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR.

1 reference

12 December 2020

Activation of the double-stranded RNA-dependent eIF-2alpha kinase by cellular RNA from 3T3-F442A cells

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12 December 2020

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

1 reference

12 December 2020

Protein phosphorylation controls translation rates

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12 December 2020

PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon.

1 reference

12 December 2020

Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA.

1 reference

12 December 2020

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation

1 reference

12 December 2020

GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae

1 reference

12 December 2020

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase

1 reference

12 December 2020

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1 reference

12 December 2020

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.

1 reference

12 December 2020

Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67).

1 reference

12 December 2020

Structure of the beta subunit of translational initiation factor eIF-2

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12 December 2020

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2

1 reference

12 December 2020

The phosphorylation of eukaryotic initiation factor 2: a principle of translational control in mammalian cells

1 reference

12 December 2020

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase

1 reference

12 December 2020

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1 reference

12 December 2020

Construction and expression of an enzymatically active human-mouse chimeric double-stranded RNA-dependent protein kinase

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12 December 2020

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

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12 December 2020

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

1 reference

12 December 2020

Inhibition of the dsRNA-dependent protein kinase by a peptide derived from the human immunodeficiency virus type 1 Tat protein

1 reference

12 December 2020

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI

1 reference

12 December 2020

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.

1 reference

12 December 2020

Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product

1 reference

12 December 2020

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

12 December 2020

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

12 December 2020

Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis

1 reference

12 December 2020

Correlation between the distribution of the reversing factor and eukaryotic initiation factor 2 in heme-deficient or double-stranded RNA-inhibited reticulocyte lysates

1 reference

12 December 2020

Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells

1 reference

12 December 2020

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

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12 December 2020

Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells

1 reference

12 December 2020

Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA

1 reference

12 December 2020

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

1 reference

12 December 2020

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

1 reference

12 December 2020

Regulation of in vitro translation by double-stranded RNA in mammalian cell mRNA preparations

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12 December 2020

Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide

1 reference

12 December 2020

Evidence that phosphorylation of eIF-2(alpha) prevents the eIF-2B-mediated dissociation of eIF-2 X GDP from the 60 S subunit of complete initiation complexes

1 reference

12 December 2020

Effects of hemin and porphyrin compounds on intersubunit disulfide formation of heme-regulated eIF-2 alpha kinase and the regulation of protein synthesis in reticulocyte lysates

1 reference

12 December 2020

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

1 reference

12 December 2020

Serum growth factors cause rapid stimulation of protein synthesis and dephosphorylation of eIF-2 in serum deprived Ehrlich cells

1 reference

12 December 2020

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

12 December 2020

The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus

1 reference

12 December 2020

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI

1 reference

12 December 2020

Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells

1 reference

12 December 2020

BALB/c-3T3 fibroblasts resistant to growth inhibition by beta interferon exhibit aberrant platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor signal transduction

1 reference

12 December 2020

Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.

1 reference

12 December 2020

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells

1 reference

12 December 2020

Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms

1 reference

12 December 2020

A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta

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12 December 2020

Complex formation by positive and negative translational regulators of GCN4.

1 reference

12 December 2020

Tumor-suppressor genes: news about the interferon connection

1 reference

12 December 2020

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function

1 reference

12 December 2020

The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells

1 reference

12 December 2020

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

1 reference

12 December 2020

The protein phosphatases involved in cellular regulation. 4. Classification of two homogeneous myosin light chain phosphatases from smooth muscle as protein phosphatase-2A1 and 2C, and a homogeneous protein phosphatase from reticulocytes active on p

1 reference

12 December 2020

Presence of haemin-controlled eIF-2 alpha kinases in both undifferentiated and differentiating mouse erythroleukaemia cells

1 reference

12 December 2020

Translational control in mammalian cells

1 reference

12 December 2020

The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

1 reference

12 December 2020

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12 December 2020

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12 December 2020

Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2.

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12 December 2020

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast

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12 December 2020

Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis.

1 reference

12 December 2020

Regulation of eukaryotic translation initiation factor expression during T-cell activation

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12 December 2020

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans

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12 December 2020

Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine

1 reference

12 December 2020

Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00986962

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7969108%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

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