GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor (Q64273034)

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27 April 2020

title

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor (English)

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Vivian Fu

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Audrey W Hong

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Fa-Xing Yu

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Delong Meng

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Wai-Ling Macrina Lam

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Hai-Xin Yuan

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Kun-Liang Guan

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language of work or name

English

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publication date

21 May 2019

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11 June 2022

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inferred from PubMed Central ID database lookup

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Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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12 December 2020

Regulation of TORC1 by Rag GTPases in nutrient response

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12 December 2020

Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation

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12 December 2020

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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12 December 2020

Bidirectional transport of amino acids regulates mTOR and autophagy

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12 December 2020

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

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12 December 2020

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

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PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells

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Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

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12 December 2020

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Glutaminolysis activates Rag-mTORC1 signaling.

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Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

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12 December 2020

Assembly of allosteric macromolecular switches: lessons from PKA

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12 December 2020

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

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12 December 2020

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12 December 2020

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Amino acid signalling upstream of mTOR

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12 December 2020

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12 December 2020

Nutrient signaling to mTOR and cell growth

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12 December 2020

DNA targeting specificity of RNA-guided Cas9 nucleases

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12 December 2020

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12 December 2020

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

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12 December 2020

Rag GTPases are cardioprotective by regulating lysosomal function.

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12 December 2020

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12 December 2020

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

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12 December 2020

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12 December 2020

Metabolism. Differential regulation of mTORC1 by leucine and glutamine

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12 December 2020

Sestrin2 is a leucine sensor for the mTORC1 pathway

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12 December 2020

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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12 December 2020

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

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12 December 2020

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

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12 December 2020

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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12 December 2020

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

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12 December 2020

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

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12 December 2020

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.

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12 December 2020

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

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12 December 2020

Structure and dynamics of GPCR signaling complexes.

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.43038

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27 April 2020

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27 April 2020

PubMed publication ID

31112131

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