Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy (Q64075248)

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scholarly article by Lylia Ouboussad et al published 2019 in Frontiers in Medicine

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English	Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy	scholarly article by Lylia Ouboussad et al published 2019 in Frontiers in Medicine

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scholarly article

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Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy (English)

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rheumatoid arthritis

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based on heuristic

inferred from title

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2

object named as

Agata N Burska

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author name string

Lylia Ouboussad

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Andrew Melville

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Maya H Buch

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language of work or name

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publication date

2019

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Frontiers in Medicine

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6

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45

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copyright license

Creative Commons Attribution 4.0 International

19 March 2019

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April 2022 Public Data File from Crossref

copyright status

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The synovial membrane of healthy individuals--immunohistochemical overlap with synovitis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

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Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Tissue cytokine patterns distinguish variants of rheumatoid synovitis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Synovial biopsy in arthritis research: five years of concerted European collaboration

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Lessons learnt from the synovial tissue response to anti-rheumatic treatment

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Histology of the synovial tissue: value of semiquantitative analysis for the prediction of joint erosions in rheumatoid arthritis.

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Systemic anti-tumor necrosis factor α therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor α synthesis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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NF-kappaB: a key role in inflammatory diseases

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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T cell activation in rheumatoid synovium is B cell dependent

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

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Receptor activator NF-kappaB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls.

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Activation of the STAT1 pathway in rheumatoid arthritis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets.

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histological patterns of synovitis and serum chemokines in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Power Doppler ultrasonography and synovitis: correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipments

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease.

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of vascular gene expression in arthritic synovium by laser-mediated microdissection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

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Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Responsiveness to anti-tumour necrosis factor alpha therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor therapy in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Remission and rheumatoid arthritis: data on patients receiving usual care in twenty-four countries

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How to perform and analyse synovial biopsies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: a prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial tissue heterogeneity and peripheral blood biomarkers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The normal synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of interleukin 6 in the pathophysiology of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creative trial design in RA: optimizing patient outcomes

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https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New learnings on the pathophysiology of RA from synovial biopsies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The arrival of JAK inhibitors: advancing the treatment of immune and hematologic disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abatacept or tocilizumab after rituximab in rheumatoid arthritis? An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and vascularisation markers of arthroscopically-guided finger joint synovial biospies reflect global disease activity in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic contrast-enhanced magnetic resonance imaging of metacarpophalangeal joints reflects histological signs of synovitis in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular heterogeneity in the Rheumatoid Arthritis synovium: clinical correlates of synovitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of synovial molecular patterns in patients with arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of Mitogen-Activated Protein Kinases in Bone and Cartilage of Patients with Rheumatoid Arthritis Treated with Abatacept

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted inhibition of Janus kinases abates interfon gamma-induced invasive behaviour of fibroblast-like synoviocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional Profiling of Synovial Macrophages using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathology of the synovial tissue: perspectives for biomarker development in chronic inflammatory arthritides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30941350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FMED.2019.00045

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