Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer (Q64054927)

12 December 2020

Analysis of antibodies to RNA in patients with systemic lupus erythematosus and other autoimmune rheumatic diseases

1 reference

12 December 2020

The natural history of uveitis

1 reference

12 December 2020

Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques

1 reference

12 December 2020

A urine inhibitor of interleukin 1 activity that blocks ligand binding.

1 reference

12 December 2020

High-dose chemoradiotherapy with bone marrow transplantation as consolidation treatment in neuroblastoma: an unselected group of stage IV patients over 1 year of age

1 reference

12 December 2020

The histochemical pattern of the human adult testes

1 reference

12 December 2020

The expanding universe of T-cell subsets: Th1, Th2 and more.

1 reference

12 December 2020

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

1 reference

12 December 2020

A family of cytokine-inducible inhibitors of signalling

1 reference

12 December 2020

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

12 December 2020

Structure and function of a new STAT-induced STAT inhibitor

1 reference

12 December 2020

Cloning and characterization of novel CIS family genes

1 reference

12 December 2020

Specific inhibition of Stat3 signal transduction by PIAS3

1 reference

12 December 2020

Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein

1 reference

12 December 2020

Distinct regulation of IL-8 and MCP-1 by LPS and interferon-gamma-treated human peritoneal macrophages

1 reference

12 December 2020

Inhibition of Stat1-mediated gene activation by PIAS1

1 reference

12 December 2020

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

12 December 2020

Heterogeneity of vascular endothelial cells: differences in susceptibility to neutrophil-mediated injury

1 reference

12 December 2020

STAT3 is required for the gp130-mediated full activation of the c-myc gene

1 reference

12 December 2020

Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells

1 reference

12 December 2020

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

12 December 2020

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

12 December 2020

Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

1 reference

12 December 2020

Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction

1 reference

12 December 2020

1 reference

12 December 2020

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

12 December 2020

Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis

1 reference

12 December 2020

IL-6 up-regulates mcl-1 in human myeloma cells through JAK / STAT rather than ras / MAP kinase pathway

1 reference

12 December 2020

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

12 December 2020

Roles of STAT3 defined by tissue-specific gene targeting

1 reference

12 December 2020

The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

1 reference

12 December 2020

Why are "natively unfolded" proteins unstructured under physiologic conditions?

1 reference

12 December 2020

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

1 reference

12 December 2020

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

1 reference

12 December 2020

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

1 reference

12 December 2020

Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances

1 reference

12 December 2020

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

12 December 2020

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

1 reference

12 December 2020

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

1 reference

12 December 2020

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

1 reference

12 December 2020

Expression of the chemokines MIP-1alpha, MCP-1, and RANTES in experimental autoimmune uveitis

1 reference

12 December 2020

Signaling by type I and II cytokine receptors: ten years after

1 reference

12 December 2020

Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cyt

1 reference

12 December 2020

A universal framework for 13C metabolic flux analysis

1 reference

12 December 2020

Distinct gene expression profiles of human type 1 and type 2 T helper cells

1 reference

12 December 2020

SOCS proteins: negative regulators of cytokine signaling

1 reference

12 December 2020

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

1 reference

12 December 2020

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

1 reference

12 December 2020

Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

1 reference

12 December 2020

Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation

1 reference

12 December 2020

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

1 reference

12 December 2020

Pim serine/threonine kinases regulate the stability of Socs-1 protein

1 reference

12 December 2020

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

1 reference

12 December 2020

Fcgamma and complement receptors: expression, role and co-operation in mediating the oxidative burst and degranulation of neutrophils of Brazilian systemic lupus erythematosus patients.

1 reference

12 December 2020

Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1

1 reference

12 December 2020

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

1 reference

12 December 2020

Uveitis in horses induced by interphotoreceptor retinoid-binding protein is similar to the spontaneous disease

1 reference

12 December 2020

Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1

1 reference

12 December 2020

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

12 December 2020

Streptococcal infection distinguishes different types of psoriasis

1 reference

12 December 2020

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

1 reference

12 December 2020

Bench to bedside: new approaches to the immunotherapy of uveitic disease

1 reference

12 December 2020

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

1 reference

12 December 2020

SOCS-1 participates in negative regulation of LPS responses

1 reference

12 December 2020

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

1 reference

12 December 2020

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

1 reference

12 December 2020

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

1 reference

12 December 2020

Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses

1 reference

12 December 2020

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

1 reference

12 December 2020

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

1 reference

12 December 2020

Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray

1 reference

12 December 2020

SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia

1 reference

12 December 2020

STATs dimerize in the absence of phosphorylation

1 reference

12 December 2020

1 reference

12 December 2020

The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse

1 reference

12 December 2020

Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms

1 reference

12 December 2020

Serum interleukin-6 levels reflect the disease status of colorectal cancer

1 reference

12 December 2020

Suppressor of cytokine signalling gene expression is elevated in breast carcinoma

1 reference

12 December 2020

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes

1 reference

12 December 2020

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.

1 reference

12 December 2020

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

1 reference

12 December 2020

Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity

1 reference

12 December 2020

Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides.

1 reference

12 December 2020

Negative regulation of FAK signaling by SOCS proteins

1 reference

12 December 2020

Role of Toll-like receptors in pathogen recognition.

1 reference

12 December 2020

Emerging Trends in Oral Delivery of Peptide and Protein Drugs

1 reference

12 December 2020

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

1 reference

12 December 2020

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

1 reference

12 December 2020

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases

1 reference

12 December 2020

The STATs of cancer--new molecular targets come of age

1 reference

12 December 2020

Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients

1 reference

12 December 2020

Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling

1 reference

12 December 2020

Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein

1 reference

12 December 2020

FERM domain interaction promotes FAK signaling

1 reference

12 December 2020

The uveitogenic potential of retinal S-antigen in horses

1 reference

12 December 2020

v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.

1 reference

12 December 2020

Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod

1 reference

12 December 2020

Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma

1 reference

12 December 2020

Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma

1 reference

12 December 2020

Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment, and Lattice System Physician's Global Assessment

1 reference

12 December 2020

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line

1 reference

12 December 2020

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

1 reference

12 December 2020

Psoriasis assessment tools in clinical trials

1 reference

12 December 2020

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

1 reference

12 December 2020

Mechanisms of type-I- and type-II-interferon-mediated signalling

1 reference

12 December 2020

The Jak/Stat pathway: a novel way to regulate PI3K activity.

1 reference

12 December 2020

Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus.

1 reference

12 December 2020

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

1 reference

12 December 2020

Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma

1 reference

12 December 2020

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

1 reference

12 December 2020

Role of Stat3 in regulating p53 expression and function

1 reference

12 December 2020

Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein

1 reference

12 December 2020

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

1 reference

12 December 2020

CD56brightCD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation

1 reference

12 December 2020

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

1 reference

12 December 2020

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

1 reference

12 December 2020

Inter- and intramolecular epitope spreading in equine recurrent uveitis

1 reference

12 December 2020

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion.

1 reference

12 December 2020

Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.

1 reference

12 December 2020

STAT3 as a downstream mediator of Trk signaling and functions

1 reference

12 December 2020

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

1 reference

12 December 2020

Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration

1 reference

12 December 2020

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

1 reference

12 December 2020

Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies

1 reference

12 December 2020

Therapeutic peptides: technological advances driving peptides into development

1 reference

12 December 2020

Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups.

1 reference

12 December 2020

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

1 reference

12 December 2020

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

1 reference

12 December 2020

National Psoriasis Foundation clinical consensus on disease severity

1 reference

12 December 2020

Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist

1 reference

12 December 2020

Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

1 reference

12 December 2020

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

12 December 2020

Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6

1 reference

12 December 2020

Pathogenesis and clinical features of psoriasis

1 reference

12 December 2020

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

1 reference

12 December 2020

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

1 reference

12 December 2020

Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity

1 reference

12 December 2020

Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents

1 reference

12 December 2020

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

1 reference

12 December 2020

Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma

1 reference

12 December 2020

Psoriasis is associated with increased beta-defensin genomic copy number

1 reference

12 December 2020

STAT3 as a target for inducing apoptosis in solid and hematological tumors

1 reference

12 December 2020

Roles of unphosphorylated STATs in signaling

1 reference

12 December 2020

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

1 reference

12 December 2020

STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-cell lymphoma.

1 reference

12 December 2020

Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics

1 reference

12 December 2020

Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases

1 reference

12 December 2020

Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate

1 reference

12 December 2020

Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.

1 reference

12 December 2020

NIH public access policy

1 reference

12 December 2020

Stem cell regulation by JAK/STAT signaling in Drosophila

1 reference

12 December 2020

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

1 reference

12 December 2020

Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling.

1 reference

12 December 2020

Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B

1 reference

12 December 2020

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

1 reference

12 December 2020

Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

1 reference

12 December 2020

Identification of a nuclear localization signal in suppressor of cytokine signaling 1.

1 reference

12 December 2020

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

1 reference

12 December 2020

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas

1 reference

12 December 2020

Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.

1 reference

12 December 2020

Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response

1 reference

12 December 2020

Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases

1 reference

12 December 2020

Pathogen recognition and inflammatory signaling in innate immune defenses

1 reference

12 December 2020

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

1 reference

12 December 2020

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.

1 reference

12 December 2020

STAT3 regulation of glioblastoma pathogenesis.

1 reference

12 December 2020

A tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-gamma signaling in lupus-affected (NZB x NZW)F1 mice

1 reference

12 December 2020

The role of IL-23/IL-17 axis in lupus nephritis

1 reference

12 December 2020

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

1 reference

12 December 2020

Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

1 reference

12 December 2020

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

1 reference

12 December 2020

Synthetic therapeutic peptides: science and market

1 reference

12 December 2020

MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus

1 reference

12 December 2020

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

1 reference

12 December 2020

Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus

1 reference

12 December 2020

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

1 reference

12 December 2020

Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation

1 reference

12 December 2020

Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice

1 reference

12 December 2020

Evidence for the presence of bacteria in the blood of psoriasis patients.

1 reference

12 December 2020

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence

1 reference

12 December 2020

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

1 reference

12 December 2020

The FERM domain: organizing the structure and function of FAK.

1 reference

12 December 2020

Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus

1 reference

12 December 2020

Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis

1 reference

12 December 2020

Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells.

1 reference

12 December 2020

The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

1 reference

12 December 2020

Activation of JAK-STAT1 signal transduction pathway in lesional skin and monocytes from patients with systemic lupus erythematosus

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses

1 reference

12 December 2020

Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts

1 reference

12 December 2020

Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus

1 reference

12 December 2020

Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

1 reference

12 December 2020

Murine models of systemic lupus erythematosus

1 reference

12 December 2020

IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3

1 reference

12 December 2020

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

12 December 2020

STAT6 expression in glioblastoma promotes invasive growth

1 reference

12 December 2020

Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis

1 reference

12 December 2020

Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients

1 reference

12 December 2020

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

1 reference

12 December 2020

Interleukin-6: a multifunctional targetable cytokine in human prostate cancer

1 reference

12 December 2020

Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2

1 reference

12 December 2020

Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation

1 reference

12 December 2020

Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis

1 reference

12 December 2020

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production

1 reference

12 December 2020

Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment

1 reference

12 December 2020

Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus

1 reference

12 December 2020

Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells.

1 reference

12 December 2020

TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis

1 reference

12 December 2020

STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

1 reference

12 December 2020

VEGF-induced vascular permeability is mediated by FAK.

1 reference

12 December 2020

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

1 reference

12 December 2020

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

1 reference

12 December 2020

β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

1 reference

12 December 2020

JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells

1 reference

12 December 2020

Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression.

1 reference

12 December 2020

Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.

1 reference

12 December 2020

Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies

1 reference

12 December 2020

Cortactin as a target for FAK in the regulation of focal adhesion dynamics

1 reference

12 December 2020

Complement, interferon and lupus

1 reference

12 December 2020

Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy.

1 reference

12 December 2020

MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1

1 reference

12 December 2020

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

1 reference

12 December 2020

Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo

1 reference

12 December 2020

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

1 reference

12 December 2020

Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis

1 reference

12 December 2020

MCP-1 in psoriatic patients: effect of biological therapy

1 reference

12 December 2020

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells

1 reference

12 December 2020

Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner

1 reference

12 December 2020

E-cadherin-integrin crosstalk in cancer invasion and metastasis

1 reference

12 December 2020

IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus

1 reference

12 December 2020

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

1 reference

12 December 2020

Retracted: IL-26 Promotes the Proliferation and Survival of Human Gastric Cancer Cells by Regulating the Balance of STAT1 and STAT3 Activation

1 reference

12 December 2020

Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy

1 reference

12 December 2020

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis

1 reference

12 December 2020

Incidence and prevalence of uveitis: results from the Pacific Ocular Inflammation Study

1 reference

12 December 2020

Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells

1 reference

12 December 2020

Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice

1 reference

12 December 2020

Neutrophil Extracellular Traps and Systemic Lupus Erythematosus

1 reference

12 December 2020

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases

1 reference

12 December 2020

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

1 reference

12 December 2020

Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus

1 reference

12 December 2020

Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare

1 reference

12 December 2020

IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model

1 reference

12 December 2020

TLR2 and TLR4 expression in atopic dermatitis, contact dermatitis and psoriasis

1 reference

12 December 2020

ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis.

1 reference

12 December 2020

Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells

1 reference

12 December 2020

JAK-cytokine receptor recognition, unboxed.

1 reference

12 December 2020

Secukinumab in plaque psoriasis--results of two phase 3 trials

1 reference

12 December 2020

Suppressor of cytokine signaling 1-derived peptide inhibits Janus kinase/signal transducers and activators of transcription pathway and improves inflammation and atherosclerosis in diabetic mice.

1 reference

12 December 2020

FAK in cancer: mechanistic findings and clinical applications

1 reference

12 December 2020

Current challenges in peptide-based drug discovery

1 reference

12 December 2020

Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6.

1 reference

12 December 2020

STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters

1 reference

12 December 2020

Strategic approaches to optimizing peptide ADME properties

1 reference

12 December 2020

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

1 reference

12 December 2020

The transcriptional response to tumorigenic polarity loss in Drosophila.

1 reference

12 December 2020

Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma

1 reference

12 December 2020

Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma

1 reference

12 December 2020

Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.

1 reference

12 December 2020

Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

1 reference

12 December 2020

SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function

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12 December 2020

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

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12 December 2020

Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis

1 reference

12 December 2020

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis.

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12 December 2020

Equine recurrent uveitis: Human and equine perspectives

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12 December 2020

Molecular Determinants for Unphosphorylated STAT3 Dimerization Determined by Integrative Modeling.

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12 December 2020

The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease.

1 reference

12 December 2020

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12 December 2020

Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

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12 December 2020

Tumour-promoting role of SOCS1 in colorectal cancer cells

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12 December 2020

Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis

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12 December 2020

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.

1 reference

12 December 2020

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells.

1 reference

12 December 2020

Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis.

1 reference

12 December 2020

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

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12 December 2020

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

1 reference

12 December 2020

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

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12 December 2020

Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.

1 reference

12 December 2020

JAK/STAT signalling mediates cell survival in response to tissue stress.

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12 December 2020

Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.

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12 December 2020

Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function.

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12 December 2020

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation

1 reference

12 December 2020

SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis).

1 reference

12 December 2020

Therapeutic Potential for Targeting the Suppressor of Cytokine Signalling-1 Pathway for the Treatment of SLE.

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12 December 2020

Update on Lupus Nephritis

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12 December 2020

Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung

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12 December 2020

A brief summary of clinical types of psoriasis.

1 reference

12 December 2020

SOCS1 favors the epithelial-mesenchymal transition in melanoma, promotes tumor progression and prevents antitumor immunity by PD-L1 expression

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12 December 2020

Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies

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12 December 2020

Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3.

1 reference

12 December 2020

IL-17 Signaling: The Yin and the Yang.

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12 December 2020

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.

1 reference

12 December 2020

SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions

1 reference

12 December 2020

Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial

1 reference

12 December 2020

Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy

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12 December 2020

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma

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12 December 2020

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

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12 December 2020

Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

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12 December 2020

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

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12 December 2020

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.

1 reference

12 December 2020

Epidemiology of uveitis in a US population-based study.

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12 December 2020

Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.

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12 December 2020

The molecular basis of JAK/STAT inhibition by SOCS1.

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12 December 2020

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.

1 reference

12 December 2020

Partial Laryngeal IMRT for T2N0 Glottic Cancer: Impact of Image Guidance and Radiation Therapy Intensification

1 reference

12 December 2020

Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance.

1 reference

12 December 2020

Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?

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12 December 2020

A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis

1 reference

12 December 2020