Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal (Q59793507)

object named as

Christopher J Schofield

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author name string

Kerstin Lippl

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Anna Boleininger

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Martine I Abboud

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2018

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published in

Hypoxia (Auckland, N.Z.)

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volume

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page(s)

57-71

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start time

1 November 2018

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Studies on non-haem ferrous-dependent oxygenases and oxidases

1 reference

12 December 2020

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

1 reference

12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 December 2020

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 December 2020

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 December 2020

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 December 2020

Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase. Identification of a previously unknown alternatively spliced exon and its expression in various tissues

1 reference

12 December 2020

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 December 2020

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 December 2020

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 December 2020

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 December 2020

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

12 December 2020

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 December 2020

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

12 December 2020

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 December 2020

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 December 2020

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme

1 reference

12 December 2020

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

12 December 2020

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

1 reference

12 December 2020

Oxygen sensing by HIF hydroxylases

1 reference

12 December 2020

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

12 December 2020

The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases

1 reference

12 December 2020

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

1 reference

12 December 2020

Proline hydroxylation and gene expression

1 reference

12 December 2020

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

1 reference

12 December 2020

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

12 December 2020

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

1 reference

12 December 2020

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

1 reference

12 December 2020

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

12 December 2020

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

12 December 2020

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

1 reference

12 December 2020

CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases

1 reference

12 December 2020

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

1 reference

12 December 2020

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS

1 reference

12 December 2020

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

12 December 2020

The human oxygen sensing machinery and its manipulation

1 reference

12 December 2020

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

1 reference

12 December 2020

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

1 reference

12 December 2020

Evidence for a stereoelectronic effect in human oxygen sensing.

1 reference

12 December 2020

The Crystal Structure of an Algal Prolyl 4-Hydroxylase Complexed with a Proline-rich Peptide Reveals a Novel Buried Tripeptide Binding Motif

1 reference

12 December 2020

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

1 reference

12 December 2020

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

1 reference

12 December 2020

A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium

1 reference

12 December 2020

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

1 reference

12 December 2020

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

1 reference

12 December 2020

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

1 reference

12 December 2020

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

1 reference

12 December 2020

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

1 reference

12 December 2020

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

1 reference

12 December 2020

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

12 December 2020

Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins

1 reference

12 December 2020

The Skp1 protein from Toxoplasma is modified by a cytoplasmic prolyl 4-hydroxylase associated with oxygen sensing in the social amoeba Dictyostelium

1 reference

12 December 2020

Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway

1 reference

12 December 2020

Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein

1 reference

12 December 2020

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

1 reference

12 December 2020

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

1 reference

12 December 2020

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

1 reference

12 December 2020

Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor.

1 reference

12 December 2020

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

1 reference

12 December 2020

Targeting Protein-Protein Interactions in the HIF System

1 reference

12 December 2020

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

1 reference

12 December 2020

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

1 reference

12 December 2020

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

1 reference

12 December 2020

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

1 reference

12 December 2020