Modifying Human Thymidylate Kinase to Potentiate Azidothymidine Activation (Q59662994)

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2 November 2019

title

Modifying human thymidylate kinase to potentiate azidothymidine activation (English)

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2 November 2019

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2 November 2019

R Brundiers

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2 November 2019

A Lavie

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2 November 2019

T Veit

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2 November 2019

J Reinstein

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2 November 2019

I Schlichting

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2 November 2019

N Ostermann

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2 November 2019

M Konrad

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2 November 2019

language of work or name

English

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publication date

1 December 1999

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Journal of Biological Chemistry

2 November 2019

published in

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2 November 2019

volume

274

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2 November 2019

issue

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2 November 2019

page(s)

35289-35292

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

2 November 2019

cites work

1 reference

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The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

The bottleneck in AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Calcium binding sites in tomato bushy stunt virus visualized by Laue crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast

21 January 2018

1 reference

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Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth

21 January 2018

1 reference

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[64] Guanylate kinases from human erythrocytes, hog brain, and rat liver

21 January 2018

1 reference

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Essential lysine residues in the N-terminal and the C-terminal domain of human adenylate kinase interact with adenine nucleotides as found by site-directed random mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Use of herpes simplex virus thymidine kinase to improve the antiviral activity of zidovudine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

21 January 2018

Improving AZT efficacy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35289

21 January 2018

Identifiers

DOI

10.1074/JBC.274.50.35289

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10585390%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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