Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway (Q57042606)

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1 November 2019

title

Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway (English)

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1 November 2019

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I E Mazzoni

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1 November 2019

F A Saïd

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1 November 2019

R Aloyz

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1 November 2019

F D Miller

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1 November 2019

D Kaplan

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1 November 2019

language of work or name

English

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publication date

1 November 1999

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1 November 2019

published in

Journal of Neuroscience

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1 November 2019

volume

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1 November 2019

issue

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1 November 2019

page(s)

9716-9727

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 November 2019

cites work

1 reference

12 December 2020

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

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12 December 2020

NGF-mediated survival depends on p21ras in chick sympathetic neurons from the superior cervical but not from lumbosacral ganglia

1 reference

12 December 2020

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1 reference

12 December 2020

Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival

1 reference

12 December 2020

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1 reference

12 December 2020

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation.

1 reference

12 December 2020

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

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12 December 2020

Induction of neurite outgrowth by MAP kinase in PC12 cells

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12 December 2020

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

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12 December 2020

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death

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12 December 2020

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

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12 December 2020

A synthetic inhibitor of the mitogen-activated protein kinase cascade

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12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

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12 December 2020

The trk proto-oncogene encodes a receptor for nerve growth factor

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12 December 2020

Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons

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12 December 2020

NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis

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12 December 2020

Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

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12 December 2020

Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.

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12 December 2020

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

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12 December 2020

Intracellular signaling pathways activated by neurotrophic factors

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12 December 2020

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

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12 December 2020

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production

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12 December 2020

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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12 December 2020

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

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12 December 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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12 December 2020

DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.

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12 December 2020

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

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12 December 2020

Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

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12 December 2020

Signal transduction by the neurotrophin receptors

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12 December 2020

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

Identification and characterization of novel substrates of Trk receptors in developing neurons

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12 December 2020

The nerve growth factor 35 years later

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12 December 2020

Concentration-dependent regulation of neuronal gene expression by nerve growth factor

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12 December 2020

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

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12 December 2020

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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12 December 2020

Evidence for p53-mediated modulation of neuronal viability.

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12 December 2020

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12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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12 December 2020

Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones

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12 December 2020

Features of apoptotic cells measured by flow cytometry

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12 December 2020

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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12 December 2020

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

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12 December 2020

Analysis of Ras protein expression in mammalian cells

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12 December 2020

p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons

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12 December 2020

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

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12 December 2020

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

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12 December 2020

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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12 December 2020

Increasing complexity of the Ras signaling pathway

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12 December 2020

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

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12 December 2020

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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12 December 2020

Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons

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12 December 2020

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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12 December 2020

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

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12 December 2020

The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor

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12 December 2020

An automated colorimetric microassay for neuronotrophic factors

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12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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12 December 2020

Bax involvement in p53-mediated neuronal cell death

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12 December 2020

Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.

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12 December 2020

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

1 reference

12 December 2020

Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.

1 reference

12 December 2020

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects

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12 December 2020

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

12 December 2020

10.1523/JNEUROSCI.19-22-09716.1999

Identifiers

DOI

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1 November 2019

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1 November 2019

PubMed publication ID

10559381

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10559381%20AND%20SRC:MED&resulttype=core&format=json