HRas proto-oncogene, GTPase (Q5635781)

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mammalian protein found in Homo sapiens
  • HRAS
  • Ras family small GTP binding protein H-Ras
  • p21ras
  • K-Ras 2
  • transforming protein p21
  • Ha-Ras
  • c-has/bas p21 protein
  • Ha-Ras1 proto-oncoprotein
  • GTPase HRas
  • transformation gene: oncogene HAMSV
  • GTP- and GDP-binding peptide B
  • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • H-Ras-1
  • c-ras-Ki-2 activated oncogene
  • c-H-ras
  • p19 H-RasIDX protein
  • Harvey rat sarcoma viral oncogene homolog
  • Harvey rat sarcoma viral oncoprotein
  • GTPase KRas
edit
Language Label Description Also known as
English
HRas proto-oncogene, GTPase
mammalian protein found in Homo sapiens
  • HRAS
  • Ras family small GTP binding protein H-Ras
  • p21ras
  • K-Ras 2
  • transforming protein p21
  • Ha-Ras
  • c-has/bas p21 protein
  • Ha-Ras1 proto-oncoprotein
  • GTPase HRas
  • transformation gene: oncogene HAMSV
  • GTP- and GDP-binding peptide B
  • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • H-Ras-1
  • c-ras-Ki-2 activated oncogene
  • c-H-ras
  • p19 H-RasIDX protein
  • Harvey rat sarcoma viral oncogene homolog
  • Harvey rat sarcoma viral oncoprotein
  • GTPase KRas

Statements

molecular function
protein binding
determination method
IPI
45 references
retrieved
1 January 2018
stated in
Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
The complex of Arl2-GTP and PDE delta: from structure to function
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Identification of a novel Rac1-interacting protein involved in membrane ruffling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Protein binding and signaling properties of RIN1 suggest a unique effector function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Ras membrane orientation and nanodomain localization generate isoform diversity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of Sos activity by intramolecular interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Allosteric gating of Son of sevenless activity by the histone domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
The structural basis of the activation of Ras by Sos
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Structural analysis of autoinhibition in the Ras activator Son of sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
A novel switch region regulates H-ras membrane orientation and signal output
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Identification of Nore1 as a potential Ras effector
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
Membrane-dependent signal integration by the Ras activator Son of sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
retrieved
1 January 2018
stated in
GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IPI
GTP binding
determination method
IDA
IEA
IMP
6 references
retrieved
1 January 2018
stated in
Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IEA
retrieved
1 January 2018
stated in
Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IDA
retrieved
1 January 2018
stated in
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IDA
cell component
plasma membrane
determination method
IDA
IEA
TAS
8 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
TAS
retrieved
1 January 2018
stated in
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
TAS
retrieved
1 January 2018
stated in
Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or protein kinase C
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IEA
retrieved
1 January 2018
stated in
Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
GOA
curator
UniProt
UniProt protein ID
P01112
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IDA
retrieved
1 January 2018
stated in
Spatial regulation of Raf kinase signaling by RKTG
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IDA
retrieved
1 January 2018
stated in
PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
determination method
IDA
biological process

Identifiers

PDB structure ID
 
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