E2F transcription factor 1 (Q5322375)

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mammalian protein found in Homo sapiens
  • retinoblastoma-binding protein 3
  • RBBP-3
  • transcription factor E2F1
  • RBAP-1
  • PRB-binding protein E2F-1
  • PBR3
  • retinoblastoma-associated protein 1
  • E2F1
edit
Language Label Description Also known as
English
E2F transcription factor 1
mammalian protein found in Homo sapiens
  • retinoblastoma-binding protein 3
  • RBBP-3
  • transcription factor E2F1
  • RBAP-1
  • PRB-binding protein E2F-1
  • PBR3
  • retinoblastoma-associated protein 1
  • E2F1

Statements

molecular function
protein binding
determination method or standard
IPI
39 references
retrieved
8 April 2019
stated in
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1)
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of E2F1 function by the nuclear corepressor KAP1
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
E2F transcriptional activation requires TRRAP and GCN5 cofactors
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic function of the retinoblastoma tumor suppressor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multimolecular complex of Par-4 and E2F1 binding to Smac promoter contributes to glutamate-induced apoptosis in human- bone mesenchymal stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Arginine methylation controls growth regulation by E2F-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retinoblastoma protein recruits histone deacetylase to repress transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
retrieved
8 April 2019
stated in
E2F-1 has dual roles depending on the cell cycle
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IPI
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IMP
ISA
ISM
NAS
5 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
ISA
retrieved
8 April 2019
stated in
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
GOA
curator
UniProt
UniProt protein ID
Q01094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IMP
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
determination method or standard
IBA
cell component
biological process
Gene Atlas image
PBB GE E2F1 2028 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D050687
subject named as
E2F1 Transcription Factor
0 references
 
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