Genetics of RAS signaling in C. elegans. (Q52182134)

26 April 2018

review article

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title

Genetics of RAS signaling in C. elegans. (English)

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26 April 2018

main subject

Caenorhabditis elegans

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Sternberg PW

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26 April 2018

author name string

Han M

series ordinal

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26 April 2018

publication date

1 November 1998

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26 April 2018

published in

Trends in Genetics

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26 April 2018

volume

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26 April 2018

issue

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26 April 2018

page(s)

466-472

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26 April 2018

Function and regulation of ras.

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Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

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Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

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Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene

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let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

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The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

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A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.

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A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.

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Ras pathways in Caenorhabditis elegans

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Vulval development in Caenorhabditis elegans

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Control and integration of cell signaling pathways during C. elegans vulval development

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C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

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A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans

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Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation

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The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK

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sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction

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The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

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The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

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The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway

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lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development

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lin-25, a gene required for vulval induction in Caenorhabditis elegans

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7 January 2021

MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction

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7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

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7 January 2021

soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

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clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans

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7 January 2021

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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7 January 2021

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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The Son of sevenless Gene Product: a Putative Activator of Ras

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Genes involved in two Caenorhabditis elegans cell-signaling pathways

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7 January 2021

LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction

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The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates

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7 January 2021

The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development

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7 January 2021

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Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

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The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development

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unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

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Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction

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Two types of RAS mutants that dominantly interfere with activators of RAS.

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7 January 2021

Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs

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Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans

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The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

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7 January 2021

The embryonic cell lineage of the nematode Caenorhabditis elegans

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Sensory regulation of male mating behavior in Caenorhabditis elegans

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Understanding cell migration guidance: lessons from sex myoblast migration in C. elegans

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Cell interactions coordinate the development of the C. elegans egg-laying system

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Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites

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7 January 2021

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

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7 January 2021

Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans

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7 January 2021

Genes that affect cell fates during the development of Caenorhabditis elegans

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7 January 2021

Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal

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7 January 2021

Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor

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7 January 2021

10.1016/S0168-9525(98)01592-3

Identifiers

DOI

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26 April 2018

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Fatcat

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24 November 2022

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26 April 2018