Solute carrier family 11 member 2 (Q5205645)

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mammalian protein found in Homo sapiens
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • DMT-1
  • Divalent metal transporter 1
  • NRAMP 2
  • SLC11A2
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
  • divalent cation transporter 1
  • natural resistance-associated macrophage protein 2
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Language Label Description Also known as
English
Solute carrier family 11 member 2
mammalian protein found in Homo sapiens
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • DMT-1
  • Divalent metal transporter 1
  • NRAMP 2
  • SLC11A2
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
  • divalent cation transporter 1
  • natural resistance-associated macrophage protein 2

Statements

molecular function
ferrous iron transmembrane transporter activity
determination method or standard
IDA
IEA
NAS
5 references
retrieved
24 October 2017
stated in
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
NAS
retrieved
24 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IEA
retrieved
24 October 2017
stated in
Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
ferrous iron transmembrane transporter activity
determination method or standard
IBA
IDA
IMP
NAS
5 references
retrieved
8 April 2019
stated in
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49281
determination method or standard
NAS
retrieved
8 April 2019
stated in
Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49281
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
8 April 2019
stated in
DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49281
determination method or standard
IBA
cell component
plasma membrane
determination method or standard
IDA
TAS
IMP
IEA
7 references
retrieved
24 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
TAS
retrieved
24 October 2017
stated in
Cellular location of proteins related to iron absorption and transport
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IMP
retrieved
24 October 2017
stated in
Evolution of differences in transport function in Slc11a family members
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IMP
retrieved
24 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IEA
retrieved
24 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IEA
retrieved
24 October 2017
stated in
Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
early endosome
determination method or standard
IDA
IEA
7 references
retrieved
24 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IEA
retrieved
24 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IEA
retrieved
24 October 2017
stated in
Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
retrieved
24 October 2017
stated in
Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P49281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49281&geneProductId=UniProtKB:P49281
determination method or standard
IDA
biological process
Gene Atlas image
PBB GE SLC11A2 203123 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Ensembl protein ID
 
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