Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. (Q52002352)

19 April 2018

review article

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title

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. (English)

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19 April 2018

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19 April 2018

language of work or name

English

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publication date

9 November 2006

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19 April 2018

published in

Nature Reviews Cancer

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19 April 2018

volume

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19 April 2018

issue

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19 April 2018

page(s)

967-974

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19 April 2018

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

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Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function

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Loss of adenomatous polyposis coli gene function disrupts thymic development

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

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Characterization of epithelial cell shedding from human small intestine.

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Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

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EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

21 January 2018

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Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

21 January 2018

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Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

21 January 2018

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Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

21 January 2018

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The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

21 January 2018

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Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

21 January 2018

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Examination of actin and microtubule dependent APC localisations in living mammalian cells

21 January 2018

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APC is a component of an organizing template for cortical microtubule networks

21 January 2018

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Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells

21 January 2018

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Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells

21 January 2018

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Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration

21 January 2018

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Asef, a link between the tumor suppressor APC and G-protein signaling

21 January 2018

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Mutated APC and Asef are involved in the migration of colorectal tumour cells

21 January 2018

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Identification of a link between the tumour suppressor APC and the kinesin superfamily

21 January 2018

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Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.

21 January 2018

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Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions

21 January 2018

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NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

21 January 2018

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

21 January 2018

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EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

21 January 2018

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Colocalization of APC and DLG at the tips of cellular protrusions in cultured epithelial cells and its dependency on cytoskeletons.

21 January 2018

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Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

21 January 2018

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IQGAP1 in cellular signaling: bridging the GAP.

21 January 2018

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IQGAP1: a key regulator of adhesion and migration

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Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium

21 January 2018

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Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes.

21 January 2018

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The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

21 January 2018

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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

21 January 2018

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Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK.

21 January 2018

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Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC

21 January 2018

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APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment

21 January 2018

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Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

21 January 2018

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Aneuploid colon cancer cells have a robust spindle checkpoint

21 January 2018

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Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

21 January 2018

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Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

21 January 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

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Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.

21 January 2018

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Cell type regulates selective segregation of mouse chromosome 7 DNA strands in mitosis

21 January 2018

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Asymmetric cell divisions promote stratification and differentiation of mammalian skin

21 January 2018

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Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells.

21 January 2018

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A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

21 January 2018

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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

21 January 2018

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Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent.

21 January 2018

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Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas

21 January 2018

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Evidence for active Wnt signaling during postresection intestinal adaptation.

21 January 2018

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Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

21 January 2018

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An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism

21 January 2018

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Self-renewal and cancer of the gut: two sides of a coin.

21 January 2018

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

21 January 2018

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The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions

21 January 2018

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Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis

21 January 2018

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Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta

21 January 2018

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A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

21 January 2018

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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

21 January 2018

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APC dosage effects in tumorigenesis and stem cell differentiation

21 January 2018

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APC gene: database of germline and somatic mutations in human tumors and cell lines

21 January 2018

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APC, signal transduction and genetic instability in colorectal cancer

21 January 2018

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WNT-3, Expressed by Motoneurons, Regulates Terminal Arborization of Neurotrophin-3-Responsive Spinal Sensory Neurons

21 January 2018

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The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro

21 January 2018

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Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium

21 January 2018

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Mutations in the APC tumour suppressor gene cause chromosomal instability

31 March 2020

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Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity.

31 March 2020

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12 December 2020

Intestinal stem cells protect their genome by selective segregation of template DNA strands.

1 reference

12 December 2020

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas

1 reference

12 December 2020

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.

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12 December 2020

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

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12 December 2020

Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer

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12 December 2020

Detection of Tumor Markers Including Carcinoembryonic Antigen, APC, and Cyclin D2 in Fine-Needle Aspiration Fluid of Breast.

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12 December 2020

APC binds to the novel protein EB1

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12 December 2020

Regulation of caspase expression and apoptosis by adenomatous polyposis coli.

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12 December 2020

Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration

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12 December 2020

Circadian variation in migration velocity in small intestinal epithelium

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12 December 2020

Identifiers

DOI

10.1038/NRC2010

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19 April 2018

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19 April 2018