Complete genomic landscape of a recurring sporadic parathyroid carcinoma (Q51042797)

27 March 2018

title

Complete genomic landscape of a recurring sporadic parathyroid carcinoma (English)

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27 March 2018

Andrew J Mungall

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Katayoon Kasaian

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27 March 2018

Sam M Wiseman

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27 March 2018

Nina Thiessen

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27 March 2018

Karen L Mungall

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27 March 2018

Richard D Corbett

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27 March 2018

Jenny Q Qian

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27 March 2018

Ka Ming Nip

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27 March 2018

Ann He

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27 March 2018

Kane Tse

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27 March 2018

Eric Chuah

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27 March 2018

Richard J Varhol

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27 March 2018

Pawan Pandoh

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27 March 2018

Helen McDonald

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27 March 2018

Thomas Zeng

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27 March 2018

Angela Tam

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27 March 2018

Jacquie Schein

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27 March 2018

Inanc Birol

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27 March 2018

Richard A Moore

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27 March 2018

Yongjun Zhao

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27 March 2018

Martin Hirst

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27 March 2018

Marco A Marra

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27 March 2018

Blair A Walker

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27 March 2018

Steven J M Jones

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27 March 2018

publication date

1 July 2013

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27 March 2018

published in

Journal of Pathology

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27 March 2018

volume

230

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27 March 2018

issue

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27 March 2018

page(s)

249-260

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27 March 2018

Hyperparathyroid and hypoparathyroid disorders

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HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours

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PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

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Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

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Phospholipase D activity is required for actin stress fiber formation in fibroblasts

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The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

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Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking

21 January 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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Ubiquitin ligases: cell-cycle control and cancer

21 January 2018

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A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure

21 January 2018

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The leucine-rich repeat as a protein recognition motif

21 January 2018

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Rabconnectin-3 is a functional regulator of mammalian Notch signaling

21 January 2018

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AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

21 January 2018

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Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action

21 January 2018

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The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway

21 January 2018

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Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting

21 January 2018

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AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

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Aberrant WNT/β-catenin signaling in parathyroid carcinoma

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Diagnosis and management of parathyroid cancer.

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A new frontier in personalized cancer therapy: mapping molecular changes.

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

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Analysis of the coding genome of diffuse large B-cell lymphoma

21 January 2018

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

21 January 2018

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The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

21 January 2018

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Dissecting the genomic complexity underlying medulloblastoma

21 January 2018

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Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

21 January 2018

1 reference

Somatic mutation of the MEN1 gene in parathyroid tumours

21 January 2018

1 reference

Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas

21 January 2018

1 reference

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.

21 January 2018

1 reference

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

21 January 2018

1 reference

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

21 January 2018

1 reference

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

21 January 2018

1 reference

Menin interacts directly with the homeobox-containing protein Pem

21 January 2018

1 reference

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

21 January 2018

1 reference

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

21 January 2018

1 reference

Active genes are tri-methylated at K4 of histone H3

21 January 2018

1 reference

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

21 January 2018

1 reference

Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas

21 January 2018

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Deletions of CDKN2C in multiple myeloma: biological and clinical implications

21 January 2018

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Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

21 January 2018

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The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

21 January 2018

1 reference

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

21 January 2018

1 reference

Expression of p18(INK4C) is down-regulated in human pituitary adenomas

21 January 2018

1 reference

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis

21 January 2018

1 reference

Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states

21 January 2018

1 reference

Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidism

21 January 2018

1 reference

Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas

21 January 2018

1 reference

Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans

21 January 2018

1 reference

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

1 reference

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

21 January 2018

1 reference

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective

21 January 2018

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Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

21 January 2018

1 reference

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

21 January 2018

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Identification of somatic mutations in parathyroid tumors using whole-exome sequencing

21 January 2018

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mTOR signaling at a glance

21 January 2018

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Activating mutations of TOR (target of rapamycin).

21 January 2018

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Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

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Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 January 2018

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

mTOR signaling: PLD takes center stage

21 January 2018

1 reference

Phospholipase D confers rapamycin resistance in human breast cancer cells

21 January 2018

1 reference

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

21 January 2018

1 reference

Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment

21 January 2018

1 reference

TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation

21 January 2018

1 reference

The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression

21 January 2018

1 reference

Regulation of cyclin D1 gene expression

21 January 2018

1 reference

Regulation of cyclin D1 RNA stability by SNIP1

21 January 2018

1 reference

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

21 January 2018

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Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

21 January 2018

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Mapping and quantifying mammalian transcriptomes by RNA-Seq

21 January 2018

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Integrative genomics viewer

21 January 2018

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dbSNP: the NCBI database of genetic variation

21 January 2018

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An integrated map of genetic variation from 1,092 human genomes

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Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancer.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4203

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27 March 2018

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27 March 2018