Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. (Q48620889)

PubMed publication ID

11978814

13 February 2018

http://europepmc.org/abstract/MED/11978814

title

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition (English)

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12 May 2020

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Mary J Savage

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758401&resulttype=core&format=json

12 May 2020

Yin-Guo Lin

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758401&resulttype=core&format=json

12 May 2020

John R Ciallella

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12 May 2020

Dorothy G Flood

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12 May 2020

Richard W Scott

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12 May 2020

language of work or name

English

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publication date

1 May 2002

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PubMed publication ID

11978814

13 February 2018

http://europepmc.org/abstract/MED/11978814

published in

Journal of Neuroscience

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12 May 2020

volume

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issue

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12 May 2020

page(s)

3376-3385

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Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

12 May 2020

cites work

1 reference

12 December 2020

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Inflammation and Alzheimer's disease

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Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system

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12 December 2020

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

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12 December 2020

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

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12 December 2020

Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway

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12 December 2020

Unbiased stereological estimation of the number of neurons in the human hippocampus

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Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

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12 December 2020

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

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Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

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12 December 2020

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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12 December 2020

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

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12 December 2020

Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

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12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

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12 December 2020

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

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12 December 2020

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

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12 December 2020

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

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12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

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12 December 2020

JNK activation is associated with intracellular beta-amyloid accumulation

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12 December 2020

A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation.

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12 December 2020

Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome

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12 December 2020

Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia

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12 December 2020

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

1 reference

12 December 2020

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

1 reference

12 December 2020

p38 kinase is activated in the Alzheimer's disease brain

1 reference

12 December 2020

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

1 reference

12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

1 reference

12 December 2020

Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.

1 reference

12 December 2020

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

12 December 2020

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

1 reference

12 December 2020

Structure, microtubule interactions, and phosphorylation of tau protein

1 reference

12 December 2020

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

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12 December 2020

Molecular mechanism of Alzheimer's neurofibrillary degeneration and therapeutic intervention

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12 December 2020

Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model

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12 December 2020

Familial Alzheimer's chromosome 14 mutations

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12 December 2020

Mammalian MAP kinase signalling cascades

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12 December 2020

Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo.

1 reference

12 December 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

12 December 2020

Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction

1 reference

12 December 2020

Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear pa

1 reference

12 December 2020

Neuron loss in APP transgenic mice

1 reference

12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

12 December 2020

Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.

1 reference

12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

12 December 2020

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1 reference

12 December 2020

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

1 reference

12 December 2020

CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults

1 reference

12 December 2020

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

1 reference

12 December 2020

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

1 reference

12 December 2020

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

12 December 2020

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

1 reference

12 December 2020

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

1 reference

12 December 2020

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

1 reference

12 December 2020

10.1523/JNEUROSCI.22-09-03376.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758401&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758401&resulttype=core&format=json

12 May 2020

PubMed publication ID

11978814

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758401&resulttype=core&format=json