The Mad2 spindle checkpoint protein has two distinct natively folded states (Q47943415)

7 February 2018

title

The Mad2 spindle checkpoint protein has two distinct natively folded states (English)

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7 February 2018

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7 February 2018

Josep Rizo

object named as

Josep Rizo

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7 February 2018

Xuelian Luo

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7 February 2018

Zhanyun Tang

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7 February 2018

Guohong Xia

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Tomohiro Matsumoto

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Hongtao Yu

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7 February 2018

publication date

14 March 2004

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Nature Structural & Molecular Biology

published in

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7 February 2018

volume

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issue

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7 February 2018

page(s)

338-345

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Segregating sister genomes: the molecular biology of chromosome separation

cites work

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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

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Regulation of APC-Cdc20 by the spindle checkpoint

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Waiting for anaphase: Mad2 and the spindle assembly checkpoint

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Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

31 March 2020

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

31 March 2020

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BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

31 March 2020

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Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner

31 March 2020

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The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

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The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

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Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

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Identification of a MAD2-binding protein, CMT2, and its role in mitosis

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Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

31 March 2020

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Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

31 March 2020

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Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

31 March 2020

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The spindle checkpoint: structural insights into dynamic signalling

31 March 2020

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Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

31 March 2020

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

31 March 2020

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Inducing precocious anaphase in cultured mammalian cells

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Antibody multispecificity mediated by conformational diversity

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Structural basis of latency in plasminogen activator inhibitor-1

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Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

31 March 2020

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Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

31 March 2020

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Phosphorylation of human MAD1 by the BUB1 kinase in vitro

31 March 2020

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NMR structure determination of proteins and protein complexes larger than 20 kDa

31 March 2020

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31 March 2020

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Protein backbone angle restraints from searching a database for chemical shift and sequence homology

31 March 2020

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

31 March 2020

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Identifiers

DOI

10.1038/NSMB748

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7 February 2018

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7 February 2018