Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity (Q47774258)

5 February 2018

title

Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity (English)

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5 February 2018

author name string

Claudia Penafuerte

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5 February 2018

Luis Alberto Perez-Quintero

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5 February 2018

Valerie Vinette

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5 February 2018

Teri Hatzihristidis

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5 February 2018

Michel L Tremblay

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5 February 2018

publication date

20 September 2017

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5 February 2018

Current Topics in Microbiology and Immunology

published in

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5 February 2018

volume

410

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5 February 2018

page(s)

191-214

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5 February 2018

An Interaction of LPS and RSV Infection in Augmenting the AHR and Airway Inflammation in Mice

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SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production

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Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

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Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts

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Clinical use of dendritic cells for cancer therapy.

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Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells

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Distinct signal codes generate dendritic cell functional plasticity

21 January 2018

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Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.

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The nature of activatory and tolerogenic dendritic cell-derived signal II.

21 January 2018

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Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

21 January 2018

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Ras and Rho GTPases: a family reunion

21 January 2018

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

21 January 2018

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PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Dendritic cell-based immunotherapy: a basic review and recent advances.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Control of macrophage metabolism and activation by mTOR and Akt signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

SOCS3 negatively regulates IL-6 signaling in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Association of LY9 in UK and Canadian SLE families

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Tissue-resident macrophages

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PTP1B: a simple enzyme for a complex world

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Signaling defects in anti-tumor T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Mechanisms and functional significance of tumour-induced dendritic-cell defects

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_68

Trial watch: Dendritic cell-based anticancer immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Inside the human cancer tyrosine phosphatome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Phosphatase regulation of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

SOCS3 regulates the plasticity of gp130 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

STAT3 is required for Flt3L-dependent dendritic cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Molecular basis of T cell inactivation by CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Diversification of dendritic cell subsets: Emerging roles for STAT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Receptor-type protein tyrosine phosphatase gamma (PTPgamma), a new identifier for myeloid dendritic cells and specialized macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

TIGIT, A Novel Therapeutic Target for Tumor Immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The TIGIT/CD226 axis regulates human T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Tumour-associated macrophages as treatment targets in oncology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

A Breakthrough: Macrophage-Directed Cancer Immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protective and pathogenic functions of macrophage subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Dendritic cells for active immunotherapy: optimizing design and manufacture in order to develop commercially and clinically viable products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Role of SHP2 in hematopoiesis and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Putting the brakes on BTLA in T cell-mediated cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protein tyrosine phosphatase 1B is a regulator of the interleukin-10-induced transcriptional program in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

TAM receptors are pleiotropic inhibitors of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Macrophages and therapeutic resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Modulation of leptin resistance by protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protein tyrosine phosphatases: from genes, to function, to disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Dendritic cell cross talk with innate and innate-like effector cells in antitumor immunity: implications for DC vaccination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Importance and mechanism of 'switch' function of SAP family adapters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

X-linked lymphoproliferative syndromes and related autosomal recessive disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

SHP-1: the next checkpoint target for cancer immunotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Molecular and cellular insights into T cell exhaustion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

Alternative splicing of CD45: the tip of the iceberg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_68

21 January 2018

Identifiers

DOI

10.1007/82_2017_68

1 reference

5 February 2018

1 reference

5 February 2018