Gamma-secretase: proteasome of the membrane? (Q44918417)

7 December 2017

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title

Gamma-secretase: proteasome of the membrane? (English)

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7 December 2017

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7 December 2017

Ma Xenia G Ilagan

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7 December 2017

publication date

1 June 2004

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Nature Reviews Molecular Cell Biology

7 December 2017

published in

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7 December 2017

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7 December 2017

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7 December 2017

page(s)

499-504

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 December 2017

cites work

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Intramembrane proteolysis controls diverse signalling pathways throughout evolution

31 March 2020

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Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus

31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

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Notch signaling: from the outside in

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex

31 March 2020

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Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

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Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis

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Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

31 March 2020

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Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium

31 March 2020

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

31 March 2020

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

31 March 2020

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

31 March 2020

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

31 March 2020

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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

31 March 2020

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The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

31 March 2020

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

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Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage

31 March 2020

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The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells

31 March 2020

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

31 March 2020

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

31 March 2020

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

31 March 2020

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Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

31 March 2020

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Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

31 March 2020

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Protein ectodomain shedding

31 March 2020

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A cell biological perspective on Alzheimer's disease

31 March 2020

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

31 March 2020

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Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

31 March 2020

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

31 March 2020

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

31 March 2020

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Alzheimer's disease. A partner for presenilin.

31 March 2020

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Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations

31 March 2020

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A role for phosphorylation and degradation in the control of NF-κB activity

31 March 2020

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Ci proteolysis: regulation by a constellation of phosphorylation sites.

31 March 2020

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Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase

31 March 2020

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Membrane-bound transcription factors: regulated release by RIP or RUP.

31 March 2020

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

31 March 2020

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A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

31 March 2020

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The proteasome: structure, function, and role in the cell

31 March 2020

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gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

31 March 2020

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Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events

31 March 2020

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Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

31 March 2020

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Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

31 March 2020

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Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

31 March 2020

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Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1406

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Dimensions Publication ID

7 December 2017

1005035720

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