Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. (Q44391314)

2 December 2017

title

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. (English)

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2 December 2017

Hiroyuki Kubota

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2 December 2017

Tohru Obata

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2 December 2017

Kazuhisa Ota

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2 December 2017

Takuma Sasaki

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2 December 2017

Takashi Ito

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2 December 2017

language of work or name

English

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publication date

2 April 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

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2 December 2017

page(s)

20457-20460

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Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

2 December 2017

cites work

1 reference

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Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

21 January 2018

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Gene-specific regulation by general translation factors

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

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The TOR kinases link nutrient sensing to cell growth

21 January 2018

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The target of rapamycin (TOR) proteins

21 January 2018

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Multiple upstream AUG codons mediate translational control of GCN4.

21 January 2018

1 reference

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GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

21 January 2018

1 reference

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The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

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Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

21 January 2018

1 reference

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

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Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast

21 January 2018

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TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation

21 January 2018

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The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.

21 January 2018

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Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

21 January 2018

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A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols

21 January 2018

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Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

21 January 2018

1 reference

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Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

21 January 2018

1 reference

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Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation

21 January 2018

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Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

21 January 2018

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The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation

21 January 2018

1 reference

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Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

21 January 2018

1 reference

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Gene overexpression reveals alternative mechanisms that induce GCN4 mRNA translation

21 January 2018

1 reference

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GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

21 January 2018

1 reference

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Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.C300133200

1 reference

release_hhzrgvobrba6bkgyt23ioxi23i

2 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hhzrgvobrba6bkgyt23ioxi23i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference