Blocking cytochrome c activity within intact neurons inhibits apoptosis. (Q41762114)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

title

Blocking cytochrome c activity within intact neurons inhibits apoptosis (English)

1 reference

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4 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

S J Neame

1 reference

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4 December 2019

K L Philpott

series ordinal

1 reference

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4 December 2019

language of work or name

English

0 references

publication date

1 September 1998

1 reference

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4 December 2019

number of pages

1 reference

inferred from page(s)

published in

Journal of Cell Biology

1 reference

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4 December 2019

volume

142

1 reference

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4 December 2019

issue

1 reference

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4 December 2019

page(s)

1583-1593

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

4 December 2019

cites work

1 reference

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Modulation of cell death by Bcl-XL through caspase interaction

6 June 2018

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

6 June 2018

1 reference

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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

6 June 2018

1 reference

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

6 June 2018

1 reference

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Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

6 June 2018

1 reference

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Conversion of Bcl-2 to a Bax-like death effector by caspases

6 June 2018

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

6 June 2018

1 reference

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Caspases: intracellular signaling by proteolysis

6 June 2018

1 reference

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Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

6 June 2018

1 reference

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Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

6 June 2018

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

6 June 2018

1 reference

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Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

6 June 2018

1 reference

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Caspases: killer proteases

6 June 2018

1 reference

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

6 June 2018

1 reference

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Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases

6 June 2018

1 reference

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Inhibition of Bax channel-forming activity by Bcl-2

6 June 2018

1 reference

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The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

6 June 2018

1 reference

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Double identity for proteins of the Bcl-2 family

6 June 2018

1 reference

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Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

6 June 2018

1 reference

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

6 June 2018

1 reference

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Channel formation by antiapoptotic protein Bcl-2.

6 June 2018

1 reference

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

6 June 2018

1 reference

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Programmed cell death in animal development

6 June 2018

1 reference

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

6 June 2018

1 reference

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

6 June 2018

1 reference

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

6 June 2018

1 reference

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Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

6 June 2018

1 reference

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Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

6 June 2018

1 reference

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Maturation of the antibody response to the major epitope on the self antigen mouse cytochrome c. Restricted V gene usage, selected mutations, and increased affinity

6 June 2018

1 reference

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Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

6 June 2018

1 reference

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Programmed cell death in the developing nervous system

6 June 2018

1 reference

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Neuronal death in developmental models: possible implications in neuropathology

6 June 2018

1 reference

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Ischemia-induced neuronal apoptosis

6 June 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

6 June 2018

1 reference

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The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

6 June 2018

1 reference

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Intracellular signaling pathways activated by neurotrophic factors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Regulation of the salvage pathway of deoxynucleotides synthesis in apoptosis induced by growth factor deprivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

6 June 2018

1 reference

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Molecular mechanisms of developmental neuronal death

6 June 2018

1 reference

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Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes

6 June 2018

1 reference

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

6 June 2018

1 reference

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Programmed cell death and the control of cell survival: lessons from the nervous system

6 June 2018

1 reference

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Signal transduction and gene regulation: the nuclear response to cAMP.

6 June 2018

1 reference

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Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.

6 June 2018

1 reference

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

6 June 2018

1 reference

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Apoptosis in the pathogenesis and treatment of disease

6 June 2018

1 reference

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The ins and outs of programmed cell death during C. elegans development

6 June 2018

1 reference

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Molecular genetics of neuronal survival

6 June 2018

1 reference

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Cell death during development of the nervous system

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Mechanisms and Functions of Cell Death

6 June 2018

1 reference

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Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Injected cytochrome c induces apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Role of CED-4 in the activation of CED-3.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Role of ribonucleotide reductase and deoxynucleotide pools in the oxygen-dependent control of DNA replication in Ehrlich ascites cells.

18 August 2018

1 reference

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Bcl-x(L) forms an ion channel in synthetic lipid membranes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

Programmed cell death and Bcl-2 protection in very low oxygen.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2141762

The role of DNA fragmentation in apoptosis

18 August 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Histochemical detection of apoptosis in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

The Bcl-2 family of proteins: regulators of cell death and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Morphological and biochemical changes in neurons: apoptosis versus mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Deoxynucleoside Induces Neuronal Apoptosis Independent of Neurotrophic Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.142.6.1583

Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation

21 January 2018

1 reference

12 December 2020

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

1 reference

12 December 2020

Involvement of caspases in sympathetic neuron apoptosis

1 reference

12 December 2020

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis

1 reference

12 December 2020

Purification and characterization of an interleukin-1beta-converting enzyme family protease that activates cysteine protease P32 (CPP32)

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.142.6.1583

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

PubMed publication ID

9744886

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9744886%20AND%20SRC:MED&resulttype=core&format=json